{"doi":"10.1093/ajcn/84.6.1340","title":"Exchangeable zinc pool size at birth is smaller in small-for-gestational-age than in appropriate-for-gestational-age preterm infants","abstract":null,"journal":"The American Journal of Clinical Nutrition","year":2006,"id":593875,"datarank":0.47670807455219194,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"self_citation_contribution":0.47670807455219194,"citation_network_contribution":0.0,"self_endowment_contribution":0.47670807455219194,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1520031,"name":"Jamie L Westcott","orcid":null,"position":1,"is_corresponding":false},{"id":1520032,"name":"Donna J Rodden","orcid":null,"position":2,"is_corresponding":false},{"id":1520033,"name":"Katharine W Ferguson","orcid":null,"position":3,"is_corresponding":false},{"id":1520034,"name":"Leland V Miller","orcid":null,"position":4,"is_corresponding":false},{"id":1520035,"name":"K Michael Hambidge","orcid":null,"position":5,"is_corresponding":false},{"id":1520030,"name":"Nancy F Krebs","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Exchangeable zinc pool size at birth is smaller in small-for-gestational-age than in appropriate-for-gestational-age preterm infants","abstract":"<h4>Background</h4>Small-for-gestational-age (SGA) infants are susceptible to postnatal zinc deficiency, but whether this susceptibility is due to intrauterine factors or to high postnatal growth requirements is unknown.<h4>Objective</h4>We hypothesized that the size of the exchangeable zinc pool (EZP), which reflects metabolically available zinc, would be smaller in SGA than in appropriate-for-gestational-age (AGA) infants born prematurely.<h4>Design</h4>Intravenous 70Zn (45 microg/kg) was administered to 10 SGA infants (8 boys) with a mean (+/-SD) gestational age of 33.3 +/- 1.8 wk and to 11 AGA infants (8 boys) with a mean (+/-SD) gestational age of 32.4 +/- 1.2 wk within 24 h of birth. The EZP was determined from isotope enrichment in spot urine collections on days 3-7.<h4>Results</h4>The mean birth weight of the SGA infants was 1.30 +/- 0.2 kg and of the AGA infants was 1.84 +/- 0.3 kg (P = 0.0001). The EZP size was significantly smaller in the SGA than in the AGA infants on an absolute basis (13.3 +/- 2.8 and 25.2 +/- 8.1 mg; P = 0.0002) and relative to body weight (10.3 +/- 2.5 and 13.9 +/- 4.5 mg/kg; P = 0.02). The difference remained significant after adjustment for gestational age and birth weight.<h4>Conclusion</h4>These data provide evidence for differential zinc status at birth between SGA and AGA infants born prematurely at similar stages of gestation and offer at least a partial explanation for the reported benefits of postnatal zinc supplementation.","is_dataset_classified":null,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17158414","pmcid":null,"openalex_id":"https://openalex.org/W2162270305","authors":[],"funders":[{"funder_name":"NIDDK NIH HHS","grant_id":"T32 DK07658","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"HD04024","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"RR00069","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"K24 RR018357-01","title":null},{"funder_name":"PHS HHS","grant_id":"U01-40657","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"P30-DK-48520","title":null}],"total_grants":6,"fwci":1.778,"citation_percentile":0.84303487,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2013,"count":1},{"year":2014,"count":1},{"year":2015,"count":1},{"year":2017,"count":1},{"year":2020,"count":1},{"year":2021,"count":1}],"oa_status":"closed","license":"http://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0002916523291947?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0002916523291947?httpAccept=text/plain","host_type":"publisher"},{"url":"http://academic.oup.com/ajcn/article-pdf/84/6/1340/23890624/znu01206001340.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/ajcn/84.6.1340","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17158414","host_type":"repository"}],"fields_of_study":["Trace Elements in Health","Selenium in Biological Systems","Heavy Metal Exposure and Toxicity","Birth Weight","Cross-Sectional Studies","Female","Gestational Age","Humans","Infant, Newborn","Infant, Premature","Infant, Small for Gestational Age","Male","Nutritional Status","Zinc","Zinc Isotopes"],"mesh_terms":["Birth Weight","Cross-Sectional Studies","Female","Gestational Age","Humans","Infant, Newborn","Infant, Premature","Infant, Small for Gestational Age","Male","Nutritional Status","Zinc","Zinc Isotopes"],"keywords":["Small for gestational age","Gestational age","Birth weight","Gestation","Medicine","Obstetrics","Appropriate for gestational age","Low birth weight","Zinc","Pediatrics","Pregnancy","Chemistry","Biology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T12:37:16.439073Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}