{"doi":"10.1093/abm/kaaf009","title":"“I’m Ready This Time”: Investigating physiological and emotional habituation to repetitive social stress","abstract":"BACKGROUND: Repetitive stress is at the nexus of acute and chronic stress, and there is limited knowledge about how physiological and emotional responses change with repeated exposure. PURPOSE: We examined stress-related biomarkers and emotional responses to repeated social stressors, and we tested behavioral moderators. METHODS: In Study 1, 42 adults completed the Trier Social Stress Test (TSST) twice, 4 months apart. Serum inflammatory cytokines (interleukin-6 [IL-6], tumor necrosis factor-α [TNF-α]), blood pressure, pulse, salivary cortisol, and state-level anxiety were measured surrounding the stressor. In Study 2, 84 married individuals completed two 20-minute discussions of contentious topics in the marriage, 1 month apart. Serum IL-6, TNF-α, blood pressure, pulse, salivary cortisol, and state affect were collected surrounding the conflict. Trained experimenters rated positive and negative behavior during the conflict. RESULTS: In the repetitive Trier paradigm, participants reported less anxiety (Ps = .048) and had higher anticipatory IL-6 responses (P = .014) at Visit 2, compared to Visit 1. In the repetitive marital conflict paradigm, participants had lower positive affect (P = .0004), as well as systolic blood pressure (SBP) (P = .009), diastolic blood pressure (P = .0003), and pulse (P = .027) habituation at the second visit. Objectively rated negative conflict behavior interacted with visit to predict TNF-α (P = .025) and SBP (P = .037) responses. Positive conflict behavior did not moderate outcomes (Ps > .06). CONCLUSIONS: Stress-sensitive systems can habituate or sensitize to even nontraumatic, repetitive social stressors. Patterns of habituation or sensitization may vary by time between repetition, type of social stressor, stress-sensitive system, and participant behavior.","journal":"Annals of Behavioral Medicine","year":2025,"id":540518,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8412,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":361949,"name":"M. Rosie Shrout","orcid":"0000-0001-5751-1782","position":1,"is_corresponding":false},{"id":417795,"name":"Stephanie J. Wilson","orcid":"0000-0002-1248-911X","position":2,"is_corresponding":false},{"id":361950,"name":"Megan E. Renna","orcid":"0000-0003-3941-4270","position":3,"is_corresponding":false},{"id":75664,"name":"Juan Peng","orcid":"0000-0001-6308-3040","position":4,"is_corresponding":false},{"id":361948,"name":"Rebecca Andridge","orcid":"0000-0001-9991-9647","position":5,"is_corresponding":false},{"id":500701,"name":"Lisa M. Jaremka","orcid":"0000-0002-7043-1215","position":6,"is_corresponding":false},{"id":1307429,"name":"Christopher P. Fagundes","orcid":"0000-0003-2526-9025","position":7,"is_corresponding":false},{"id":298116,"name":"Martha A. Belury","orcid":"0000-0002-6480-4281","position":8,"is_corresponding":false},{"id":361951,"name":"William B. Malarkey","orcid":"0000-0002-1021-995X","position":9,"is_corresponding":false},{"id":361953,"name":"Janice K. Kiecolt‐Glaser","orcid":"0000-0003-4900-9578","position":10,"is_corresponding":false},{"id":361947,"name":"Annelise A. Madison","orcid":"0000-0001-6091-6844","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:52:38.861025Z","pmid":"40036285","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}