{"doi":"10.1093/abm/kaac048","title":"An Examination of the Longitudinal Relationship Between Cognitive Function and Physical Activity Among Older Breast Cancer Survivors in the Thinking and Living With Cancer Study","abstract":"BACKGROUND: Older cancer survivors are at risk for cognitive decline. Physical activity can improve cognition, and better cognitive function may facilitate greater physical activity. PURPOSE: We examined the potential bidirectional relationship between cognitive function and physical activity in older breast cancer survivors and controls. METHODS: The sample included women with newly diagnosed, nonmetastatic breast cancer (n = 395) and women without cancer (n = 374) ages 60-98. Participants were recruited as part of a larger multisite study, assessed prior to systemic therapy, and followed yearly for 36 months. Attention, processing speed, and executive function was measured using six neuropsychological tests, self-reported cognitive function using the Perceived Cognitive Impairments subscale of the Functional Assessment of Cancer Therapy-Cognitive Function , and physical activity using the International Physical Activity Questionnaire-Short Form. Separate random intercepts cross-lagged panel models were used to examine the between- and within-person effects for survivors and controls, controlling for age, education, and study site. RESULTS: Survivors reported significantly less physical activity than controls at baseline (1,284.92 vs. 2,085.98 MET min/week, p < .05). When survivors reported higher activity, they simultaneously had better objective cognition at 12 months (β = 0.24, p = .04) and reported better perceived cognition at 12 and 24 months (β = 0.25, p = .03), but this relationship was not seen in controls. Cognition did not predict subsequent physical activity or vice versa in either group. CONCLUSIONS: Cognition and physical activity are cross-sectionally associated in survivors, but the expected prospective relationships were not found.","journal":"Annals of Behavioral Medicine","year":2022,"id":266194,"datarank":0.5144202828584918,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.15473599193873616,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.15473599193873616,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":9,"citers_with_citation_signal":5,"citers_with_endowment":5,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9516,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":770219,"name":"Catherine E. Mosher","orcid":"0000-0002-9689-5392","position":1,"is_corresponding":false},{"id":826469,"name":"Melissa A. Cyders","orcid":"0000-0003-1990-8337","position":2,"is_corresponding":false},{"id":260693,"name":"Brenna C. McDonald","orcid":"0000-0001-6895-4490","position":3,"is_corresponding":false},{"id":27595,"name":"Andrew J. Saykin","orcid":"0000-0002-1376-8532","position":4,"is_corresponding":false},{"id":337738,"name":"Brent J. Small","orcid":"0000-0002-7444-4689","position":5,"is_corresponding":false},{"id":403482,"name":"Wanting Zhai","orcid":null,"position":6,"is_corresponding":false},{"id":402362,"name":"Xingtao Zhou","orcid":"0000-0002-5164-125X","position":7,"is_corresponding":false},{"id":337736,"name":"Heather Jim","orcid":"0000-0001-7353-3711","position":8,"is_corresponding":false},{"id":337741,"name":"Paul B. Jacobsen","orcid":"0000-0002-4427-8800","position":9,"is_corresponding":false},{"id":278735,"name":"Tim A. Ahles","orcid":"0000-0002-7936-2818","position":10,"is_corresponding":false},{"id":402364,"name":"James C. Root","orcid":"0000-0001-7332-6165","position":11,"is_corresponding":false},{"id":402363,"name":"Deena Graham","orcid":"0000-0003-1111-6984","position":12,"is_corresponding":false},{"id":426788,"name":"Sunita K. Patel","orcid":"0000-0002-9023-8391","position":13,"is_corresponding":false},{"id":292842,"name":"Jeanne S. Mandelblatt","orcid":"0000-0002-2490-005X","position":14,"is_corresponding":false},{"id":356060,"name":"Danielle B. Tometich","orcid":"0000-0002-5939-0635","position":0,"is_corresponding":true}],"reference_count":62,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:26:54.081997Z","pmid":"36356044","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}