{"doi":"10.1093/abm/kaaa004","title":"The Effect of Pain Catastrophizing on Endogenous Inhibition of Pain and Spinal Nociception in Native Americans: Results From the Oklahoma Study of Native American Pain Risk","abstract":"BACKGROUND: Conditioned pain modulation (CPM) is a task that involves measuring pain in response to a test stimulus before and during a painful conditioning stimulus (CS). The CS pain typically inhibits pain elicited by the test stimulus; thus, this task is used to assess endogenous pain inhibition. Moreover, less efficient CPM-related inhibition is associated with chronic pain risk. Pain catastrophizing is a cognitive-emotional process associated with negative pain sequelae, and some studies have found that catastrophizing reduces CPM efficiency. PURPOSE: The current study examined the relationship between catastrophizing (dispositional and situation specific) and CPM-related inhibition of pain and the nociceptive flexion reflex (NFR; a marker of spinal nociception) to determine whether the catastrophizing-CPM relationship might contribute to the higher risk of chronic pain in Native Americans (NAs). METHODS: CPM of pain and NFR was assessed in 124 NAs and 129 non-Hispanic Whites. Dispositional catastrophizing was assessed at the beginning of the test day, whereas situation-specific catastrophizing was assessed in response to the CS, as well as painful electric stimuli. RESULTS: Situation-specific, but not dispositional, catastrophizing led to less NFR inhibition but more pain inhibition. These effects were not moderated by race, but mediation analyses found that: (a) the NA race was associated with greater situation-specific catastrophizing, which led to less NFR inhibition and more pain inhibition, and (b) situation-specific catastrophizing was associated with greater CS pain, which led to more pain inhibition. CONCLUSIONS: Catastrophizing may contribute to NA pain risk by disrupting descending inhibition.","journal":"Annals of Behavioral Medicine","year":2020,"id":77189,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9613,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":402226,"name":"B. Kuhn","orcid":"0000-0001-6533-400X","position":1,"is_corresponding":false},{"id":403433,"name":"M. Payne","orcid":null,"position":2,"is_corresponding":false},{"id":402227,"name":"E. Lannon","orcid":"0000-0002-3847-5920","position":3,"is_corresponding":false},{"id":371222,"name":"Shreela Palit","orcid":"0000-0001-5125-1879","position":4,"is_corresponding":false},{"id":402228,"name":"C. Sturycz","orcid":"0000-0002-8250-0126","position":5,"is_corresponding":false},{"id":402229,"name":"Natalie Hellman","orcid":"0000-0003-4811-2346","position":6,"is_corresponding":false},{"id":402230,"name":"Y. Güereca","orcid":"0000-0002-3801-0226","position":7,"is_corresponding":false},{"id":403434,"name":"Mara J. Demuth","orcid":null,"position":8,"is_corresponding":false},{"id":402231,"name":"Felicitas A. Huber","orcid":"0000-0001-6728-6750","position":9,"is_corresponding":false},{"id":402232,"name":"Joanna O. Shadlow","orcid":"0000-0002-5956-3428","position":10,"is_corresponding":false},{"id":402233,"name":"Jamie L. Rhudy","orcid":"0000-0002-5785-1880","position":11,"is_corresponding":false},{"id":402225,"name":"Tyler A. Toledo","orcid":"0000-0003-0054-1352","position":0,"is_corresponding":true}],"reference_count":77,"raw_metadata":null,"created_at":"2026-07-18T21:48:50.085103Z","pmid":"32073117","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}