{"doi":"10.1091/mbc.e23-12-0488","title":"The myosin chaperone UNC-45 has an important role in maintaining the structure and function of muscle sarcomeres during adult aging","abstract":"C. elegans undergo age-dependent declines in muscle organization and function, similar to human sarcopenia. The chaperone UNC-45 is required to fold myosin heads after translation and is likely used for refolding after thermally- or chemically-induced unfolding. UNC-45′s TPR region binds HSP-90 and its UCS domain binds myosin heads. We observe early onset sarcopenia when UNC-45 is reduced at the beginning of adulthood. There is sequential decline of HSP-90, UNC-45, and MHC B myosin. A mutation in age-1 delays sarcopenia and loss of HSP-90, UNC-45, and myosin. UNC-45 undergoes age-dependent phosphorylation, and mass spectrometry reveals phosphorylation of six serines and two threonines, seven of which occur in the UCS domain. Additional expression of UNC-45 results in maintenance of MHC B myosin and suppression of A-band disorganization in old animals. Our results suggest that increased expression or activity of UNC-45 might be a strategy for prevention or treatment of sarcopenia.","journal":"Molecular Biology of the Cell","year":2024,"id":455928,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9525,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":380550,"name":"Hiroshi Qadota","orcid":"0000-0002-6769-9464","position":1,"is_corresponding":false},{"id":707618,"name":"Aaron O. Bailey","orcid":"0000-0001-8063-3032","position":2,"is_corresponding":false},{"id":1280386,"name":"Silvana Valdebenito-Silva","orcid":null,"position":3,"is_corresponding":false},{"id":380553,"name":"Andrés F. Oberhauser","orcid":"0000-0001-7375-7109","position":4,"is_corresponding":false},{"id":380554,"name":"Guy M. Benian","orcid":"0000-0002-8236-3176","position":5,"is_corresponding":false},{"id":826258,"name":"Courtney J. Matheny","orcid":"0000-0001-7707-5180","position":0,"is_corresponding":true}],"reference_count":77,"raw_metadata":null,"created_at":"2026-07-19T02:03:22.974789Z","pmid":"38809582","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}