{"doi":"10.1091/mbc.e22-05-0176","title":"Rap1 regulates apical contractility to allow embryonic morphogenesis without tissue disruption and acts in part via Canoe-independent mechanisms","abstract":"<jats:p> Embryonic morphogenesis is powered by dramatic changes in cell shape and arrangement, driven by the cytoskeleton connected to adherens junctions. The role of the small GTPase Rap1 and its GEF Dizzy is explored, using Drosophila as a model. Rap1 regulates apical contractility and epithelial integrity, using Canoe and additional effectors. </jats:p>","journal":"Molecular Biology of the Cell","year":2023,"id":657068,"datarank":0.4566783656585135,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.0,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":684670,"name":"Kristi D. Yow","orcid":"0000-0002-7223-3538","position":1,"is_corresponding":false},{"id":1003535,"name":"Noah J. Gurley","orcid":"0000-0002-5682-8574","position":2,"is_corresponding":false},{"id":1003534,"name":"Melissa Greene","orcid":"0009-0007-6832-5310","position":3,"is_corresponding":false},{"id":342923,"name":"Mark Peifer","orcid":"0000-0003-1412-3987","position":4,"is_corresponding":false},{"id":342922,"name":"Kia Z. Perez-Vale","orcid":"0000-0003-2262-1679","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Rap1 regulates apical contractility to allow embryonic morphogenesis without tissue disruption and acts in part via Canoe-independent mechanisms","abstract":"<jats:p> Embryonic morphogenesis is powered by dramatic changes in cell shape and arrangement, driven by the cytoskeleton connected to adherens junctions. The role of the small GTPase Rap1 and its GEF Dizzy is explored, using Drosophila as a model. Rap1 regulates apical contractility and epithelial integrity, using Canoe and additional effectors. </jats:p>","is_dataset_classified":null,"base_score":3.044522437723423,"endowment":3.044522437723423,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36287827","pmcid":"PMC9816648","openalex_id":"https://openalex.org/W4307342669","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"R35 GM118096","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"F31 GM131521","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R35GM118096-09","title":"Regulating cell fate and shaping the body plan during morphogenesis and their alteration during oncogenesis"},{"funder_name":"National Institutes of Health","grant_id":"1F31GM131521-01A1","title":"Defining the molecular mechanisms underlying apical-basal polarity establishment and morphogenesis"}],"total_grants":4,"fwci":2.1679,"citation_percentile":0.87197082,"influential_citations":0,"citation_trend":[{"year":2022,"count":1},{"year":2023,"count":9},{"year":2024,"count":4},{"year":2025,"count":5},{"year":2026,"count":1}],"oa_status":"green","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial-Share Alike 4.0 International Creative Commons License.","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9816648","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9816648","host_type":"repository"},{"url":"https://doi.org/10.1091/mbc.e22-05-0176","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36287827","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9816648","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9816648?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1091/mbc.E22-05-0176","host_type":""}],"fields_of_study":["Cellular Mechanics and Interactions","Hippo pathway signaling and YAP/TAZ","Developmental Biology and Gene Regulation","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Shelterin Complex","Animals","Drosophila","Drosophila melanogaster","Morphogenesis","Guanine Nucleotide Exchange Factors","Adherens Junctions","Drosophila Proteins","Telomere-Binding Proteins","Embryonic Development"],"keywords":["Cell biology","Rap1","Morphogenesis","Biology","Adherens junction","Guanine nucleotide exchange factor","Actin cytoskeleton","Effector","Rac GTP-Binding Proteins","Regulator","Actin","Cytoskeleton","Cell polarity","Cadherin","GTPase","Genetics","Cell","RAC1","Signal transduction","Gene","Telomere-Binding Proteins","Embryonic Development","Articles","Adherens Junctions","Shelterin Complex","Drosophila melanogaster","Animals","Drosophila Proteins","Guanine Nucleotide Exchange Factors","Drosophila"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life below water"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T23:35:05.806288Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}