{"doi":"10.1091/mbc.e21-02-0088","title":"Myosin dilated cardiomyopathy mutation S532P disrupts actomyosin interactions, leading to altered muscle kinetics, reduced locomotion, and cardiac dilation in <i>Drosophila</i>","abstract":"We explored the mechanism of human myosin–induced dilated cardiomyopathy (DCM) using the Drosophila melanogaster model system. We discovered that the S532P myosin DCM mutation reduces the actin-dependent ATPase activity and the actin-binding rate and increases the actin-detachment rate, leading to reduced muscle function and cardiac dilation.","journal":"Molecular Biology of the Cell","year":2021,"id":192938,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.952,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":455805,"name":"Karen H. Hsu","orcid":null,"position":1,"is_corresponding":false},{"id":761363,"name":"Joy T. Puthawala","orcid":null,"position":2,"is_corresponding":false},{"id":80987,"name":"Meera Viswanathan","orcid":"0000-0003-3486-8126","position":3,"is_corresponding":false},{"id":760704,"name":"Amy K. Loya","orcid":"0000-0002-1802-8111","position":4,"is_corresponding":false},{"id":355536,"name":"Thomas C. Irving","orcid":"0000-0003-4848-3323","position":5,"is_corresponding":false},{"id":337481,"name":"Anthony Cammarato","orcid":"0000-0003-1104-4407","position":6,"is_corresponding":false},{"id":449796,"name":"Douglas M. Swank","orcid":"0000-0002-2552-4455","position":7,"is_corresponding":false},{"id":454974,"name":"Sanford I. Bernstein","orcid":"0000-0001-7094-5390","position":8,"is_corresponding":false},{"id":760703,"name":"Adriana S. Trujillo","orcid":"0000-0002-0030-5715","position":0,"is_corresponding":true}],"reference_count":70,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:49:47.463744Z","pmid":"34081531","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}