{"doi":"10.1091/mbc.e17-05-0294","title":"Moesin is involved in polarity maintenance and cortical remodeling during asymmetric cell division","abstract":"<jats:p>An intact actomyosin network is essential for anchoring polarity proteins to the cell cortex and maintaining cell size asymmetry during asymmetric cell division of Drosophila neuroblasts (NBs). However, the mechanisms that control changes in actomyosin dynamics during asymmetric cell division remain unclear. We find that the actin-binding protein, Moesin, is essential for NB proliferation and mitotic progression in the developing brain. During metaphase, phosphorylated Moesin (p-Moesin) is enriched at the apical cortex, and loss of Moesin leads to defects in apical polarity maintenance and cortical stability. This asymmetric distribution of p-Moesin is determined by components of the apical polarity complex and Slik kinase. During later stages of mitosis, p-Moesin localization shifts more basally, contributing to asymmetric cortical extension and myosin basal furrow positioning. Our findings reveal Moesin as a novel apical polarity protein that drives cortical remodeling of dividing NBs, which is essential for polarity maintenance and initial establishment of cell size asymmetry.</jats:p>","journal":"Molecular Biology of the Cell","year":2018,"id":673251,"datarank":0.42498200160843247,"base_score":2.833213344056216,"endowment":2.833213344056216,"self_citation_contribution":0.42498200160843247,"citation_network_contribution":0.0,"self_endowment_contribution":0.42498200160843247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1759027,"name":"Andrew J. Simmonds","orcid":null,"position":1,"is_corresponding":false},{"id":1089791,"name":"Sarah C. Hughes","orcid":"0000-0001-7540-1624","position":2,"is_corresponding":false},{"id":1005515,"name":"Namal Abeysundara","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Moesin is involved in polarity maintenance and cortical remodeling during asymmetric cell division","abstract":"<jats:p>An intact actomyosin network is essential for anchoring polarity proteins to the cell cortex and maintaining cell size asymmetry during asymmetric cell division of Drosophila neuroblasts (NBs). However, the mechanisms that control changes in actomyosin dynamics during asymmetric cell division remain unclear. We find that the actin-binding protein, Moesin, is essential for NB proliferation and mitotic progression in the developing brain. During metaphase, phosphorylated Moesin (p-Moesin) is enriched at the apical cortex, and loss of Moesin leads to defects in apical polarity maintenance and cortical stability. This asymmetric distribution of p-Moesin is determined by components of the apical polarity complex and Slik kinase. During later stages of mitosis, p-Moesin localization shifts more basally, contributing to asymmetric cortical extension and myosin basal furrow positioning. Our findings reveal Moesin as a novel apical polarity protein that drives cortical remodeling of dividing NBs, which is essential for polarity maintenance and initial establishment of cell size asymmetry.</jats:p>","is_dataset_classified":null,"base_score":2.833213344056216,"endowment":2.833213344056216,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29282284","pmcid":"PMC6014166","openalex_id":"https://openalex.org/W2778956398","authors":[],"funders":[{"funder_name":"NIH HHS","grant_id":"P40 OD018537","title":null},{"funder_name":"National Institutes of Health","grant_id":"3P40OD018537-04S1","title":"Bloomington Drosophila Stock Center at Indiana University"}],"total_grants":2,"fwci":0.6094,"citation_percentile":0.66994302,"influential_citations":0,"citation_trend":[{"year":2018,"count":1},{"year":2019,"count":4},{"year":2020,"count":1},{"year":2021,"count":2},{"year":2022,"count":4},{"year":2023,"count":3},{"year":2024,"count":1}],"oa_status":"green","license":"CC BY NC SA","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6014166","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6014166","host_type":"repository"},{"url":"https://syndication.highwire.org/content/doi/10.1091/mbc.E17-05-0294","host_type":"publisher"},{"url":"https://doi.org/10.1091/mbc.e17-05-0294","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29282284","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC6014166","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC6014166","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC6014166?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1091/mbc.E17-05-0294","host_type":""},{"url":"https://dx.doi.org/10.1091/mbc.e17-05-0294","host_type":""}],"fields_of_study":["Developmental Biology and Gene Regulation","Hippo pathway signaling and YAP/TAZ","Neurobiology and Insect Physiology Research","0301 basic medicine","0303 health sciences","03 medical and health sciences","Actin Cytoskeleton","Actomyosin","Animals","Asymmetric Cell Division","Cell Membrane","Cell Polarity","Drosophila","Drosophila Proteins","Metaphase","Microfilament Proteins","Neural Stem Cells","Phosphorylation","Protein Serine-Threonine Kinases"],"mesh_terms":["Actomyosin","Animals","Cell Membrane","Drosophila","Metaphase","Microfilament Proteins","Actin Cytoskeleton","Phosphorylation","Cell Polarity","Protein Serine-Threonine Kinases","Drosophila Proteins","Neural Stem Cells","Asymmetric Cell Division"],"keywords":["Moesin","Cell biology","Cell polarity","Biology","Radixin","Cell division","Asymmetric cell division","Mitosis","Cell cortex","Polarity (international relations)","Ezrin","Neuroblast","Apical cell","Cytoskeleton","Cell","Biochemistry","Neurogenesis","Cell Membrane","Microfilament Proteins","Articles","Actomyosin","Protein Serine-Threonine Kinases","Actin Cytoskeleton","Neural Stem Cells","Animals","Drosophila Proteins","Drosophila","Phosphorylation","Metaphase"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T12:50:07.567377Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}