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As endosomes traffic, they remain bound to the ER, which causes the tubular ER to rearrange its structure around dynamic endosomes at contact sites. Finally, as endosomes transition through steps of maturation, they become more tightly associated with the ER. The major implication of these results is that endosomes mature and traffic while coupled to the ER membrane rather than in isolation.</jats:p>","journal":"Molecular Biology of the Cell","year":2013,"id":615040,"datarank":0.8675737773494607,"base_score":5.783825182329737,"endowment":5.783825182329737,"self_citation_contribution":0.8675737773494607,"citation_network_contribution":0.0,"self_endowment_contribution":0.8675737773494607,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":324,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":6,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1585055,"name":"Jared R. 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In animal cells, it also requires trafficking of endosomes on microtubules. Recent work has revealed the presence of contact sites between some endosomes and the endoplasmic reticulum (ER). Although these contact sites are believed to have multiple functions, the frequency, dynamics, and physical attributes of these contacts are poorly understood. Here we use high-resolution three-dimensional electron microscopy to reveal that ER tubules wrap around endosomes and find that both organelles contact microtubules at or near membrane contact sites. As endosomes traffic, they remain bound to the ER, which causes the tubular ER to rearrange its structure around dynamic endosomes at contact sites. Finally, as endosomes transition through steps of maturation, they become more tightly associated with the ER. The major implication of these results is that endosomes mature and traffic while coupled to the ER membrane rather than in isolation.</jats:p>","is_dataset_classified":null,"base_score":5.783825182329737,"endowment":5.783825182329737,"datacite_reuse_total":6,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23389631","pmcid":"PMC3608491","openalex_id":"https://openalex.org/W1998416648","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"GM08759","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"GM083977","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"T32 GM007135","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"GM07135","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"T32 GM142607","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM083977","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"T32 GM008759","title":null},{"funder_name":"National Institutes of 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