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Under these conditions, secretion of the vesicular stomatitis virus glycoprotein protein as a marker for protein transport along the secretory pathway is inhibited, suggesting a loss of Golgi function as well. These results imply the involvement of a luminal protein in Golgi structure and function.</jats:p>","journal":"Molecular Biology of the Cell","year":2007,"id":601256,"datarank":0.41588830833596724,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.0,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1541605,"name":"Dora Kaloyanova","orcid":null,"position":1,"is_corresponding":false},{"id":163243,"name":"Martin van Eijk","orcid":null,"position":2,"is_corresponding":false},{"id":1541606,"name":"Ruud Eerland","orcid":null,"position":3,"is_corresponding":false},{"id":71009,"name":"Gisou van der Goot","orcid":null,"position":4,"is_corresponding":false},{"id":885785,"name":"Viola Oorschot","orcid":"0000-0002-8122-8271","position":5,"is_corresponding":false},{"id":560410,"name":"Judith Klumperman","orcid":"0000-0003-4835-6228","position":6,"is_corresponding":false},{"id":1518360,"name":"Friedrich Lottspeich","orcid":null,"position":7,"is_corresponding":false},{"id":5870,"name":"Vytaute Starkuviene","orcid":null,"position":8,"is_corresponding":false},{"id":120496,"name":"Felix T. 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GREG resides in the Golgi lumen as a cis-oriented homodimer, due to strong interactions between coiled-coil regions in the C termini. Dimerization of GREG as well as its Golgi localization depends on a unique tandem repeat sequence within the coiled-coil region. RNA-mediated interference of GREG expression or expression of GREG mutants reveals an essential role for GREG in maintenance of the Golgi integrity. Under these conditions, secretion of the vesicular stomatitis virus glycoprotein protein as a marker for protein transport along the secretory pathway is inhibited, suggesting a loss of Golgi function as well. 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