{"doi":"10.1089/whr.2024.0131","title":"Gender Disparities in COVID-19 Survivors with Impaired Quality of Life, Effort Intolerance, and Cardiopulmonary Symptoms: A Prospective Cohort Study","abstract":"Background: Prior studies have suggested gender differences in COVID-related outcomes that have the potential to impact cardiovascular risk. We aimed to investigate gender differences on short- and long-term effects of COVID-19 infection. Methods: Patients hospitalized with COVID-19 infection were enrolled in an ongoing prospective registry across NY-Presbyterian networks, which encompassed same-day echocardiogram, cardiac magnetic resonance (CMR), 6-minute walk test, and quality of life assessment 1 year following acute COVID hospitalization. Results: In this prospective cohort of 213 hospitalized patients with COVID-19 infection, males were more likely to require intensive care unit (ICU) stay (13.6 vs. 3.6%; p = 0.009) and oxygen supplementation (40.8 vs. 26.4%; p = 0.026), paralleling higher rates of elevated troponin, C-reactive protein, ferritin, and D-dimer ( p < 0.05 for all). In contrast, 1 year following COVID hospitalization, females reported worse physical function and fatigue on Patient-Reported Outcomes Measurement Information System (PROMIS) scale ( p < 0.05 for all). Additionally, 6-minute walk distance was less in females than males (383.0 ± 98.0 vs. 428.6 ± 78.6 m; p = 0.006), and Borg dyspnea score was nearly twofold higher in females vs. males (2.0 ± 2.3 vs. 1.0 ± 1.5; p < 0.001). With respect to imaging parameters, females had higher left ventricle and right ventricle ejection fraction ( p < 0.05 for all) with smaller infarct size ( p = 0.042) on CMR. Conclusion: Whereas males have greater morbidity during acute COVID hospitalization, females are disproportionately impacted by post-COVID impaired functional status despite higher biventricular ejection fraction and smaller infarct size.","journal":"Women s Health Reports","year":2025,"id":560994,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8938,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1463292,"name":"Dustin Wessells","orcid":null,"position":1,"is_corresponding":false},{"id":1462975,"name":"Prianca Tawde","orcid":"0000-0002-6338-2224","position":2,"is_corresponding":false},{"id":1358773,"name":"Mahniz Reza","orcid":null,"position":3,"is_corresponding":false},{"id":1168965,"name":"Caitlin Chiu","orcid":"0009-0005-9506-7981","position":4,"is_corresponding":false},{"id":1264916,"name":"Pablo Villar Calle","orcid":"0000-0001-7249-7667","position":5,"is_corresponding":false},{"id":275090,"name":"Alexander Volodarskiy","orcid":"0000-0003-4420-5000","position":6,"is_corresponding":false},{"id":275096,"name":"Evelyn M. Horn","orcid":"0000-0002-5751-9415","position":7,"is_corresponding":false},{"id":228353,"name":"Parag Goyal","orcid":"0000-0001-7474-3737","position":8,"is_corresponding":false},{"id":232193,"name":"Jonathan W. Weinsaft","orcid":"0000-0002-8386-0297","position":9,"is_corresponding":false},{"id":275089,"name":"Jiwon Kim","orcid":"0000-0002-8420-8604","position":10,"is_corresponding":false},{"id":1462974,"name":"K Varghese Zachariah","orcid":"0000-0003-3058-9023","position":0,"is_corresponding":true}],"reference_count":15,"raw_metadata":null,"created_at":"2026-07-19T02:55:46.921885Z","pmid":"40007886","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}