{"doi":"10.1089/neu.1994.11.523","title":"Endogenous Phosphorylation of a 61,000 Dalton Hippocampal Protein Increases Following Traumatic Brain Injury","abstract":null,"journal":"Journal of Neurotrauma","year":1994,"id":630402,"datarank":0.38474240361923057,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.0,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1633130,"name":"WILLIAM C. TAFT","orcid":null,"position":1,"is_corresponding":false},{"id":1633131,"name":"C. EDWARD DIXON","orcid":null,"position":2,"is_corresponding":false},{"id":1633132,"name":"ROBERT K. YU","orcid":null,"position":3,"is_corresponding":false},{"id":1633133,"name":"RONALD L. HAYES","orcid":null,"position":4,"is_corresponding":false},{"id":1633129,"name":"KEYI YANG","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Endogenous Phosphorylation of a 61,000 Dalton Hippocampal Protein Increases Following Traumatic Brain Injury","abstract":"Acute biochemical consequences of moderate traumatic brain injury (TBI) include activation of kinases, including protein kinase C (PKC). To determine the possible consequences of PKC activation at the substrate level, we have examined protein phosphorylation patterns 1 h following injury. Although the phosphorylation of most proteins remained unchanged following injury, we observed a significant increase in the phosphorylation of a 61,000 dalton protein (TBI61) in injured rat hippocampus (121% higher than sham control) in vitro. TBI61 phosphorylation could be enhanced by phosphatidyl serine and diacylglycerol or by addition of exogenous PKC. In addition, TBI61 phosphorylation was inhibited by the PKC inhibitor, staurosporine, suggesting further that this protein may be a PKC substrate. These data suggest that TBI increases the phosphorylation of a 61 kD hippocampal protein in vitro. Increases in the protein level and activity of PKC could contribute to this increased phosphorylation.","is_dataset_classified":null,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"7861445","pmcid":null,"openalex_id":"https://openalex.org/W1979712037","authors":[],"funders":[{"funder_name":"NINDS NIH HHS","grant_id":"NS21458","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"NS31998","title":null}],"total_grants":2,"fwci":1.807,"citation_percentile":0.83956405,"influential_citations":0,"citation_trend":[{"year":2014,"count":1},{"year":2016,"count":1}],"oa_status":"closed","license":"http://www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/","oa_locations":[{"url":"http://www.liebertpub.com/doi/pdf/10.1089/neu.1994.11.523","host_type":"publisher"},{"url":"https://doi.org/10.1089/neu.1994.11.523","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/7861445","host_type":"repository"}],"fields_of_study":["Traumatic Brain Injury and Neurovascular Disturbances","Traumatic Brain Injury Research","Mitochondrial Function and Pathology","Alkaloids","Animals","Brain Injuries","Diglycerides","Enzyme Activation","Hippocampus","Male","Molecular Weight","Nerve Tissue Proteins","Phosphatidylserines","Phosphorylation","Protein Kinase C","Rats","Rats, Sprague-Dawley","Staurosporine"],"mesh_terms":["Alkaloids","Animals","Brain Injuries","Diglycerides","Enzyme Activation","Hippocampus","Male","Molecular Weight","Nerve Tissue Proteins","Phosphatidylserines","Phosphorylation","Protein Kinase C","Rats, Sprague-Dawley","Staurosporine","Rats"],"keywords":["Phosphorylation","Protein kinase C","Protein phosphorylation","Staurosporine","Kinase","Hippocampal formation","Diacylglycerol kinase","Protein kinase A","Substrate-level phosphorylation","Traumatic brain injury","Hippocampus","Cell biology","Biology","Chemistry","Internal medicine","Endocrinology","Medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T21:12:38.625452Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}