{"doi":"10.1089/nat.2017.0681","title":"RNA Interference-Mediated Gene Silencing by Branched Tripodal RNAs Does Not Require Dicer Processing","abstract":null,"journal":"Nucleic Acid Therapeutics","year":2018,"id":608199,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1561947,"name":"Young Gyu Kang","orcid":null,"position":1,"is_corresponding":false},{"id":1561948,"name":"Jeong Yong Choe","orcid":null,"position":2,"is_corresponding":false},{"id":1561949,"name":"Dooyoung Lee","orcid":null,"position":3,"is_corresponding":false},{"id":1561950,"name":"Chanseok Shin","orcid":null,"position":4,"is_corresponding":false},{"id":132995,"name":"Sun Woo Hong","orcid":null,"position":5,"is_corresponding":false},{"id":133003,"name":"Dong-ki Lee","orcid":null,"position":6,"is_corresponding":false},{"id":1561946,"name":"Yanghee Kim","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"RNA Interference-Mediated Gene Silencing by Branched Tripodal RNAs Does Not Require Dicer Processing","abstract":"Specific gene silencing through RNA interference (RNAi) holds great promise as the next-generation therapeutic development platform. Previously, we have shown that branched, tripodal interfering RNA (tiRNA) structures could simultaneously trigger RNAi-mediated gene silencing of three target genes with 38 nt-long guide strands associated with Argonaute 2. Herein, we show that the branched RNA structure can trigger effective gene silencing in Dicer knockout cell line, demonstrating that the Dicer-mediated processing is not required for tiRNA activity. The finding of this study confirms the flexibility of the structure of RNAi triggers as well as the length of the guide strand in RNAi-mediated gene silencing.","is_dataset_classified":null,"base_score":2.302585092994046,"endowment":2.302585092994046,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29195056","pmcid":null,"openalex_id":"https://openalex.org/W2772937300","authors":[],"funders":[],"total_grants":0,"fwci":0.4372,"citation_percentile":0.63764584,"influential_citations":0,"citation_trend":[{"year":2019,"count":4},{"year":2021,"count":2},{"year":2022,"count":1},{"year":2023,"count":1},{"year":2024,"count":1}],"oa_status":"closed","license":"http://www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/","oa_locations":[{"url":"http://www.liebertpub.com/doi/full-xml/10.1089/nat.2017.0681","host_type":"publisher"},{"url":"http://www.liebertpub.com/doi/pdf/10.1089/nat.2017.0681","host_type":"publisher"},{"url":"https://doi.org/10.1089/nat.2017.0681","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29195056","host_type":"repository"}],"fields_of_study":["RNA Interference and Gene Delivery","Advanced biosensing and bioanalysis techniques","Bacteriophages and microbial interactions","Argonaute Proteins","Base Sequence","Cell Line","DEAD-box RNA Helicases","Genes, Reporter","HeLa Cells","Humans","Luciferases","Mesenchymal Stem Cells","MicroRNAs","Nucleic Acid Conformation","Proto-Oncogene Proteins c-met","RNA Interference","RNA, Small Interfering","Ribonuclease III","Survivin","beta Catenin","RNA, Guide, CRISPR-Cas Systems"],"mesh_terms":["Survivin","RNA, Guide, CRISPR-Cas Systems","Base Sequence","Cell Line","HeLa Cells","Humans","Luciferases","Nucleic Acid Conformation","RNA, Guide, Kinetoplastida","Genes, Reporter","Proto-Oncogene Proteins c-met","RNA Interference","RNA, Small Interfering","MicroRNAs","Ribonuclease III","beta Catenin","DEAD-box RNA Helicases","Mesenchymal Stem Cells","Argonaute Proteins","Hela Cells"],"keywords":["Dicer","RNA interference","Argonaute","Trans-acting siRNA","Gene silencing","RNA-induced silencing complex","RNA silencing","Small interfering RNA","Biology","RNA-induced transcriptional silencing","Cell biology","Small hairpin RNA","Gene","Genetics","RNA","Computational biology","Tripodal Rna"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Partnerships for the goals"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T07:41:15.131529Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}