{"doi":"10.1089/met.2023.0180","title":"Effects of Weight Loss and Weight Maintenance on Lipoprotein Insulin Resistance Scores in Adults with Overweight and Obesity","abstract":"Background:An elevated lipoprotein insulin resistance (LP-IR) score corresponds to insulin resistance in adults with overweight and obesity, yet data are lacking regarding the impact of exercise interventions on LP-IR. The purpose of this secondary analysis was to evaluate the effects of a weight loss and weight maintenance intervention on LP-IR score in adults with overweight and obesity. Methods:Thirty sedentary adults with overweight and obesity completed a 10-week OPTIFAST® weight loss program with supervised aerobic exercise to achieve clinical weight loss (CWL) (≥7% from baseline). Aerobic exercise volume increased weekly until 700 MET min/week was reached. Participants who reached CWL were randomized to groups at volumes at either physical activity (PA-REC) or weight maintenance (WM-REC) recommendations (weeks 11–28). Plasma blood samples were analyzed via nuclear magnetic resonance spectroscopy at baseline, after weight loss (week 10), and following weight maintenance (week 28). Results:Following the weight loss phase, on average, participants significantly (p < 0.001) reduced LP-IR score (−12.1 ± 13.5), body weight (−8.9 ± 2.7%), and waist circumference (−7.7 ± 4.1 cm). During the weight maintenance phase, there were no changes in LP-IR score between exercise groups (PA-REC: 4.1 ± 13.6; WM-REC: −2.0 ± 11.2; P = 0.7). The PA-REC group had improvements in LP-IR score from baseline (49.8 ± 24.6 to 36.6 ± 27.6, P < 0.001), yet there were no within-group changes during the weight maintenance phase (P > 0.05). Conclusion:LP-IR score improved during weight loss in adults with overweight and obesity and were sustained during the weight maintenance phase in the PA-REC group. Aerobic exercise at least at minimum guidelines following CWL can preserve LP-IR score improvements and may indicate a reduced T2DM risk in adults with overweight and obesity.","journal":"Metabolic Syndrome and Related Disorders","year":2024,"id":502357,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9551,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":785904,"name":"Joshua E. McGee","orcid":"0000-0003-0855-1862","position":1,"is_corresponding":false},{"id":1352280,"name":"Allison N. Bartlett","orcid":null,"position":2,"is_corresponding":false},{"id":785905,"name":"Taylor T. Brown","orcid":"0000-0001-5389-2944","position":3,"is_corresponding":false},{"id":786403,"name":"Marie C. Clunan","orcid":null,"position":4,"is_corresponding":false},{"id":786402,"name":"Anna C. Huff","orcid":null,"position":5,"is_corresponding":false},{"id":786405,"name":"Briceida G. Osborne","orcid":null,"position":6,"is_corresponding":false},{"id":785907,"name":"Laura E. Matarese","orcid":"0000-0002-8484-6622","position":7,"is_corresponding":false},{"id":672435,"name":"Walter J. Pories","orcid":"0000-0002-5768-7507","position":8,"is_corresponding":false},{"id":235344,"name":"Joseph A. Houmard","orcid":"0000-0003-3682-5410","position":9,"is_corresponding":false},{"id":785906,"name":"Robert A. Carels","orcid":"0000-0003-4067-5750","position":10,"is_corresponding":false},{"id":21934,"name":"Mark A. Sarzynski","orcid":"0000-0001-6705-0668","position":11,"is_corresponding":false},{"id":785903,"name":"Damon L. Swift","orcid":"0000-0001-6223-6930","position":12,"is_corresponding":false},{"id":1130123,"name":"Emily E. Grammer","orcid":"0000-0001-7811-0785","position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:10:23.709105Z","pmid":"39163283","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}