{"doi":"10.1089/mab.2018.0037","title":"Detection of Alpaca Podoplanin by Immunohistochemistry Using the Antibovine Podoplanin Monoclonal Antibody PMab-44","abstract":"<jats:p>Podoplanin (PDPN) is expressed in type I alveolar cells of the lungs, lymphatic endothelial cells, and podocytes of the kidneys, and induces platelet aggregation through the C-type lectin-like receptor-2. PDPNs of various animal species have been characterized using specific anti-PDPN monoclonal antibodies (mAbs). However, alpaca PDPN has not previously been characterized because antialpaca PDPN mAbs have not yet been developed. In this study, we investigated the potential cross-reaction between established antibovine PDPN mAbs and alpaca PDPN. Using immunohistochemical analysis, type I alveolar cells of the alpaca lungs were detected by the antibovine PDPN mAb, PMab-44. These results indicate that PMab-44 may be useful for the detection of alpaca PDPN.</jats:p>","journal":"Monoclonal Antibodies in Immunodiagnosis &amp; Immunotherapy","year":2018,"id":636912,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1653486,"name":"Shinji Yamada","orcid":null,"position":1,"is_corresponding":false},{"id":1653487,"name":"Shunsuke Itai","orcid":null,"position":2,"is_corresponding":false},{"id":809233,"name":"Satoru Konnai","orcid":"0000-0002-3230-7109","position":3,"is_corresponding":false},{"id":1653490,"name":"Atsushi Kobayashi","orcid":null,"position":4,"is_corresponding":false},{"id":988273,"name":"Mika K. Kaneko","orcid":"0000-0002-4158-9208","position":5,"is_corresponding":false},{"id":988274,"name":"Yukinari Kato","orcid":"0000-0001-5385-8201","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Detection of Alpaca Podoplanin by Immunohistochemistry Using the Antibovine Podoplanin Monoclonal Antibody PMab-44","abstract":"<jats:p>Podoplanin (PDPN) is expressed in type I alveolar cells of the lungs, lymphatic endothelial cells, and podocytes of the kidneys, and induces platelet aggregation through the C-type lectin-like receptor-2. PDPNs of various animal species have been characterized using specific anti-PDPN monoclonal antibodies (mAbs). However, alpaca PDPN has not previously been characterized because antialpaca PDPN mAbs have not yet been developed. In this study, we investigated the potential cross-reaction between established antibovine PDPN mAbs and alpaca PDPN. Using immunohistochemical analysis, type I alveolar cells of the alpaca lungs were detected by the antibovine PDPN mAb, PMab-44. These results indicate that PMab-44 may be useful for the detection of alpaca PDPN.</jats:p>","is_dataset_classified":null,"base_score":1.791759469228055,"endowment":1.791759469228055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30570440","pmcid":null,"openalex_id":"https://openalex.org/W2906362660","authors":[],"funders":[],"total_grants":0,"fwci":0.4113,"citation_percentile":0.65540007,"influential_citations":0,"citation_trend":[{"year":2019,"count":4},{"year":2020,"count":1}],"oa_status":"closed","license":"https://journals.sagepub.com/page/policies/text-and-data-mining-license","oa_locations":[{"url":"https://journals.sagepub.com/doi/full-xml/10.1089/mab.2018.0037","host_type":"publisher"},{"url":"https://journals.sagepub.com/doi/pdf/10.1089/mab.2018.0037","host_type":"publisher"},{"url":"https://doi.org/10.1089/mab.2018.0037","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30570440","host_type":"repository"}],"fields_of_study":["Lymphatic System and Diseases","Lymphatic Disorders and Treatments","Animals","Antibodies, Monoclonal","Antibody Specificity","Camelids, New World","Cattle","Epitopes","Immunochemistry","Membrane Glycoproteins","Podoplanin"],"mesh_terms":["Podoplanin","Animals","Antibodies, Monoclonal","Antibody Specificity","Epitopes","Camelids, New World","Cattle","Immunochemistry","Membrane Glycoproteins"],"keywords":["Podoplanin","Immunohistochemistry","Monoclonal antibody","Alveolar cells","Lymphatic system","Antibody","Pathology","Chemistry","Biology","Medicine","Immunology","Internal medicine","Lung","Pmab-44","Alpaca Pdpn","Alpaca Podoplanin"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T17:57:19.858293Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}