{"doi":"10.1089/lgbt.2023.0394","title":"Mental Health Diagnoses and Suicidality Among Transgender Youth in Hospital Settings","abstract":"Purpose: The purpose of this analysis is to: 1) describe the most common mental health diagnoses in the emergency department (ED) and inpatient hospital settings among transgender and gender diverse (TGD) youth vs. matched controls and 2) evaluate if a gender-affirming hormone therapy (GAHT) or gonadotropin-releasing hormone agonist (GnRHa) prescription decreased the risk of suicidality within these settings. Methods: Using the PEDSnet dataset (years 2009–2019), TGD youth aged 8–18 ( n = 3414, with a median age at last visit of 16.2 [14.4, 17.7] years, were propensity-score matched to controls ( n = 13,628, age 16.6 [14.2, 18.3] years). Relative risks of the most common mental health diagnoses within ED and inpatient settings were calculated for TGD youth compared with controls. Recurrent time-to-event analysis was used to examine whether GAHT or GnRHa attenuated the risk of suicidality among subsamples of TGD youth. Results: TGD youth had a higher relative risk (95% confidence interval [CI]) of mental health diagnoses and suicidality in the ED (5.46 [4.71–6.33]) and inpatient settings (6.61 [5.28–8.28]) than matched controls. TGD youth prescribed GAHT had a 43.6% lower risk of suicidality (hazard ratio [HR] = 0.564 [95% CI 0.36–0.89]) compared with those never prescribed GAHT during our study period or before GAHT initiation. TGD youth who were prescribed GnRHa therapy had a nonstatistically significant reduction in ED or inpatient suicidality diagnoses compared with those never prescribed GnRHa (HR = 0.79 [0.47–1.31]). Conclusion: Although risk of mental health diagnoses and suicidality in ED and inpatient settings was high among TGD youth, a GAHT prescription was associated with a significant reduction in suicidality risk.","journal":"LGBT Health","year":2025,"id":529680,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8676,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":675065,"name":"Anna Furniss","orcid":"0000-0001-5498-607X","position":1,"is_corresponding":false},{"id":1118368,"name":"Samuel Cortez","orcid":"0000-0001-6534-8751","position":2,"is_corresponding":false},{"id":278326,"name":"Shanlee Davis","orcid":"0000-0002-0304-9550","position":3,"is_corresponding":false},{"id":282497,"name":"Nadia Dowshen","orcid":"0000-0002-8466-1628","position":4,"is_corresponding":false},{"id":317121,"name":"Anne E. Kazak","orcid":"0000-0003-0553-0855","position":5,"is_corresponding":false},{"id":385066,"name":"Leena Nahata","orcid":"0000-0003-3899-2642","position":6,"is_corresponding":false},{"id":254435,"name":"Laura Pyle","orcid":"0000-0001-5577-8221","position":7,"is_corresponding":false},{"id":503179,"name":"Daniel Reirden","orcid":"0000-0002-4391-2718","position":8,"is_corresponding":false},{"id":675069,"name":"Beth I. Schwartz","orcid":"0000-0002-1013-6847","position":9,"is_corresponding":false},{"id":294567,"name":"Gina M. Sequeira","orcid":"0000-0001-5906-869X","position":10,"is_corresponding":false},{"id":497788,"name":"Natalie Nokoff","orcid":"0000-0002-9190-3947","position":11,"is_corresponding":false},{"id":1409014,"name":"Marissa Nunes-Moreno","orcid":"0000-0002-4719-8398","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:51:01.235017Z","pmid":"39016468","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}