{"doi":"10.1089/jwh.2022.0484","title":"Age-Dependent Sex Differences in the Prevalence of Selective Serotonin Reuptake Inhibitor Treatment: A Retrospective Cohort Analysis","abstract":"Background: Antidepressants are among the most prescribed medications in the United States. The aim of this study was to explore the prevalence of antidepressant prescriptions and investigate sex differences and age-sex interactions in adults enrolled in the Right Drug, Right Dose, Right Time: Using Genomic Data to Individualize Treatment (RIGHT) study. Materials and Methods: We conducted a retrospective analysis of the RIGHT study. Using electronic prescriptions, we assessed 12-month prevalence of antidepressant treatment. Sex differences and age-sex interactions were evaluated using multivariable logistic regression and flexible recursive smoothing splines. Results: The sample consisted of 11,087 participants (60% women). Antidepressant prescription prevalence was 22.24% (27.96% women, 13.58% men). After adjusting for age and enrollment year, women had significantly greater odds of antidepressant prescription (odds ratio = 2.29; 95% confidence interval = 2.07, 2.54). Furthermore, selective serotonin reuptake inhibitors (SSRIs) had a significant age-sex interaction. While SSRI prescriptions in men showed a sustained decrease with age, there was no such decline for women until after reaching ∼50 years of age. There are important limitations to consider in this study. Electronic prescription data were cross-sectional; information on treatment duration or adherence was not collected; this cohort is not nationally representative; and enrollment occurred over a broad period, introducing confounding by changes in temporal prescribing practices. Conclusions: Underscored by the significant interaction between age and sex on odds of SSRI prescription, our results warrant age to be incorporated as a mediator when investigating sex differences in mental illness, especially mood disorders and their treatment.","journal":"Journal of Women s Health","year":2023,"id":354329,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.5935,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1101438,"name":"Nicole I. Leibman","orcid":"0000-0002-4669-4576","position":1,"is_corresponding":false},{"id":339334,"name":"Nicholas B. Larson","orcid":"0000-0002-3468-4215","position":2,"is_corresponding":false},{"id":649842,"name":"Gregory D. Jenkins","orcid":"0000-0001-6408-6227","position":3,"is_corresponding":false},{"id":1101439,"name":"Ahmed T. Ahmed","orcid":"0000-0002-0272-7495","position":4,"is_corresponding":false},{"id":889669,"name":"Nicolás A. Núñez","orcid":"0000-0003-0404-3529","position":5,"is_corresponding":false},{"id":40725,"name":"Joanna M. Biernacka","orcid":"0000-0001-9350-4440","position":6,"is_corresponding":false},{"id":33559,"name":"Stacey J. Winham","orcid":"0000-0002-8492-9102","position":7,"is_corresponding":false},{"id":270363,"name":"Richard M. Weinshilboum","orcid":"0000-0002-4911-7985","position":8,"is_corresponding":false},{"id":228987,"name":"Liewei Wang","orcid":"0000-0003-3818-8531","position":9,"is_corresponding":false},{"id":70828,"name":"Mark A. Frye","orcid":"0000-0001-6997-4215","position":10,"is_corresponding":false},{"id":466975,"name":"Ayşegül Özerdem","orcid":"0000-0002-9455-5896","position":11,"is_corresponding":false},{"id":1101437,"name":"Jorge A. Sánchez-Ruiz","orcid":"0000-0003-4282-7359","position":0,"is_corresponding":true}],"reference_count":70,"raw_metadata":null,"created_at":"2026-07-19T01:13:06.959762Z","pmid":"37856151","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}