{"doi":"10.1089/jwh.2022.0163","title":"Boosting Dose of Pfizer–BioNtech mRNA Vaccine Against SARS-CoV-2 Does Not Affect Reproductive Outcomes in In-Vitro Fertilization Patients: A Cohort Study","abstract":null,"journal":"Journal of Women's Health","year":2023,"id":616223,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1588656,"name":"Adama Smadja","orcid":null,"position":1,"is_corresponding":false},{"id":1588658,"name":"Maor Kabessa","orcid":null,"position":2,"is_corresponding":false},{"id":1588661,"name":"Hadas Allouche kam","orcid":null,"position":3,"is_corresponding":false},{"id":1588663,"name":"Lea Nevo","orcid":null,"position":4,"is_corresponding":false},{"id":1588666,"name":"Miri Godin","orcid":null,"position":5,"is_corresponding":false},{"id":1562570,"name":"Yaakov Bentov","orcid":null,"position":6,"is_corresponding":false},{"id":677894,"name":"Ofer Beharier","orcid":"0000-0001-5317-4512","position":7,"is_corresponding":false},{"id":1588667,"name":"Efrat Esh Broder","orcid":null,"position":8,"is_corresponding":false},{"id":1588669,"name":"Hananel Holzer","orcid":null,"position":9,"is_corresponding":false},{"id":1562572,"name":"Anat Hershko Klement","orcid":"0000-0002-0330-5470","position":10,"is_corresponding":false},{"id":1588655,"name":"Chana Adler Lazarovits","orcid":"0000-0001-5507-8217","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Boosting Dose of Pfizer–BioNtech mRNA Vaccine Against SARS-CoV-2 Does Not Affect Reproductive Outcomes in In-Vitro Fertilization Patients: A Cohort Study","abstract":"Background: Since the introduction of anti-COVID-19 mRNA vaccination, few studies have shown that reproductive outcomes in artificial reproductive technology (ART) treatments are not impaired, after receiving the two-dose regimen. Our aim was to investigate whether a boosting dose of the Pfizer–BioNtech mRNA vaccine affects reproductive outcomes in ART patients. Materials and Methods: This is a prospective observational study, including 157 consecutive in-vitro fertilization (IVF) cycles between October 1, 2021, and November 24, 2021, in a single university affiliated IVF unit. We included female patients going through an ART procedure and male partners in cases of utilization of a fresh sperm sample. The study population was divided into four groups according to exposure status: vaccinated and boosted patients (three total doses of Pfizer–BioNtech mRNA vaccine), patients who were vaccinated without the booster dose (one or two vaccine doses), PCR-confirmed convalescent COVID-19 patients, and unvaccinated nonconvalescent patients. Main outcome measure was clinical pregnancy rate. Results: In total, 99 (63%) female patients were vaccinated three times, 24 (15.3%) were vaccinated without the booster dose, 21 (13.4%) were convalescent, and 13 were (8.3%) unexposed. Although age differed between study groups, vaccination exposure status did not affect treatment outcome: clinical pregnancy rates, maximal estradiol levels, and number of oocytes retrieved did not differ significantly between study groups (p = 0.78, 0.50, and 0.97, respectively). Vaccinated patients who received a boosting vaccine dose were treated within 43.3 ± 30.9 days after receiving the last dose, whereas vaccinated, nonboosted, or convalescent patients were treated 168.7 ± 53 and 209.6 ± 85.1 days after their last exposure, respectively. We stratified the male cohort according to boosting vaccine dose status. Sperm concentration and motility did not differ significantly after boosting (p = 0.49 and 0.49, respectively). Conclusions: Our results provide further reassurance that IVF outcomes are not affected by the anti-SARS-CoV-2 Pfizer–BioNtech mRNA vaccine, in particular the three-dose regimen.","is_dataset_classified":null,"base_score":2.302585092994046,"endowment":2.302585092994046,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36413046","pmcid":null,"openalex_id":"https://openalex.org/W4309657410","authors":[],"funders":[],"total_grants":0,"fwci":1.4162,"citation_percentile":0.81651029,"influential_citations":0,"citation_trend":[{"year":2023,"count":7},{"year":2024,"count":1}],"oa_status":"closed","license":"https://www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/","oa_locations":[{"url":"https://www.liebertpub.com/doi/full-xml/10.1089/jwh.2022.0163","host_type":"publisher"},{"url":"https://www.liebertpub.com/doi/pdf/10.1089/jwh.2022.0163","host_type":"publisher"},{"url":"https://doi.org/10.1089/jwh.2022.0163","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36413046","host_type":"repository"}],"fields_of_study":["COVID-19 Impact on Reproduction","Reproductive System and Pregnancy","Assisted Reproductive Technology and Twin Pregnancy","Male","Female","Pregnancy","Humans","Cohort Studies","SARS-CoV-2","COVID-19 Vaccines","COVID-19","Semen","Fertilization in Vitro","Fertilization","mRNA Vaccines"],"mesh_terms":["COVID-19","SARS-CoV-2","COVID-19 Vaccines","mRNA Vaccines","Female","Fertilization","Fertilization in Vitro","Humans","Male","Pregnancy","Semen","Cohort Studies"],"keywords":["Medicine","Vaccination","Regimen","Pregnancy","In vitro fertilisation","Booster dose","Population","Cohort","Prospective cohort study","Internal medicine","Immunology","Immunization","Antibody","Biology","Sperm","In Vitro Fertilization","Mrna Vaccines","Covid-19","Covid-19 Vaccines"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T22:19:36.019640Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}