{"doi":"10.1089/hum.2015.074","title":"Delivery and Specificity of CRISPR/Cas9 Genome Editing Technologies for Human Gene Therapy","abstract":null,"journal":"Human Gene Therapy","year":2015,"id":672131,"datarank":0.7917171988845778,"base_score":5.278114659230518,"endowment":5.278114659230518,"self_citation_contribution":0.7917171988845778,"citation_network_contribution":0.0,"self_endowment_contribution":0.7917171988845778,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":195,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":235423,"name":"Patrick D. 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Achieving this goal requires not only characterization of the technology for efficacy and specificity but also optimization of its delivery to the target cells for each disease indication. In this review we survey the various methods by which the CRISPR-Cas9 components have been delivered to cells and highlight some of the more clinically relevant approaches. Additionally, we discuss the methods available for assessing the specificity of Cas9 editing; an important safety consideration for development of the technology.","is_dataset_classified":null,"base_score":5.278114659230518,"endowment":5.278114659230518,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26068008","pmcid":null,"openalex_id":"https://openalex.org/W2147256573","authors":[],"funders":[],"total_grants":0,"fwci":11.4174,"citation_percentile":0.99059729,"influential_citations":0,"citation_trend":[{"year":2015,"count":6},{"year":2016,"count":29},{"year":2017,"count":32},{"year":2018,"count":16},{"year":2019,"count":29},{"year":2020,"count":12},{"year":2021,"count":17},{"year":2022,"count":17},{"year":2023,"count":15},{"year":2024,"count":14},{"year":2025,"count":5},{"year":2026,"count":3}],"oa_status":"closed","license":"http://www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/","oa_locations":[{"url":"http://www.liebertpub.com/doi/full-xml/10.1089/hum.2015.074","host_type":"publisher"},{"url":"http://www.liebertpub.com/doi/pdf/10.1089/hum.2015.074","host_type":"publisher"},{"url":"https://doi.org/10.1089/hum.2015.074","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26068008","host_type":"repository"}],"fields_of_study":["CRISPR and Genetic Engineering","Virus-based gene therapy research","Pluripotent Stem Cells Research","Bacterial Proteins","CRISPR-Associated Protein 9","CRISPR-Cas Systems","Clustered Regularly Interspaced Short Palindromic Repeats","Endonucleases","Genetic Therapy","Humans"],"mesh_terms":["CRISPR-Associated Protein 9","Bacterial Proteins","Endonucleases","Humans","Genetic Therapy","Clustered Regularly Interspaced Short Palindromic Repeats","CRISPR-Cas Systems"],"keywords":["CRISPR","Genome editing","Cas9","Genetic enhancement","Computational biology","Biology","Palindrome","Genome","Gene","Computer science","Genetics"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T06:42:01.270435Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}