{"doi":"10.1089/dna.2013.2300","title":"Interplay Between HDAC6 and Its Interacting Partners: Essential Roles in the Aggresome-Autophagy Pathway and Neurodegenerative Diseases","abstract":null,"journal":"DNA and Cell Biology","year":2014,"id":637880,"datarank":0.6535063240034389,"base_score":4.356708826689592,"endowment":4.356708826689592,"self_citation_contribution":0.6535063240034389,"citation_network_contribution":0.0,"self_endowment_contribution":0.6535063240034389,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":77,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":569774,"name":"Jin Yan","orcid":"0000-0002-0116-7705","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Interplay Between HDAC6 and Its Interacting Partners: Essential Roles in the Aggresome-Autophagy Pathway and Neurodegenerative Diseases","abstract":"Cytoplasmic localization and possession of two deacetylase domains and a ubiquitin-binding domain make histone deacetylase 6 (HDAC6) a unique histone deacetylase. HDAC6 interacts with a number of proteins in the cytoplasm. Some of these proteins can be deacetylated by HDAC6 deacetylase activity. Others can affect HDAC6 functions by modulating its catalytic activity or ubiquitin-binding capability. Over the last decade, HDAC6 has been shown to play important roles in the aggresome-autophagy pathway, which selectively targets on protein aggregates or damaged organelles for their accumulation and clearance in cells. HDAC6-interacting partners are integral components in this pathway with regard to their regulatory roles through interaction with HDAC6. The aggresome-autophagy pathway appears to be an attractive therapeutic target for the treatment of neurodegenerative diseases as accumulation of protein aggregates are hallmarks in these diseases. In the current review, I discuss the molecular details of how HDAC6 and its interacting partners regulate each individual step in the aggresome-autophagy pathway and also provide perspectives of how HDAC6 can be targeted in treating neurodegenerative diseases.","is_dataset_classified":null,"base_score":4.356708826689592,"endowment":4.356708826689592,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24932665","pmcid":null,"openalex_id":"https://openalex.org/W2170913652","authors":[],"funders":[],"total_grants":0,"fwci":2.9884,"citation_percentile":0.92158744,"influential_citations":0,"citation_trend":[{"year":2015,"count":9},{"year":2016,"count":6},{"year":2017,"count":8},{"year":2018,"count":7},{"year":2019,"count":4},{"year":2020,"count":9},{"year":2021,"count":11},{"year":2022,"count":9},{"year":2023,"count":4},{"year":2024,"count":6},{"year":2025,"count":3},{"year":2026,"count":1}],"oa_status":"closed","license":"http://www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/","oa_locations":[{"url":"http://www.liebertpub.com/doi/full-xml/10.1089/dna.2013.2300","host_type":"publisher"},{"url":"http://www.liebertpub.com/doi/pdf/10.1089/dna.2013.2300","host_type":"publisher"},{"url":"https://doi.org/10.1089/dna.2013.2300","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24932665","host_type":"repository"}],"fields_of_study":["Histone Deacetylase Inhibitors Research","Autophagy in Disease and Therapy","Ubiquitin and proteasome pathways","Animals","Autophagy","Histone Deacetylase 6","Histone Deacetylases","Humans","Microtubule-Organizing Center","Mitophagy","Neurodegenerative Diseases","Protein Interaction Maps","Protein Transport","Proteolysis","Ubiquitin-Protein Ligases","Ubiquitination","alpha-Synuclein","tau Proteins"],"mesh_terms":["Histone Deacetylase 6","Animals","Autophagy","Histone Deacetylases","Humans","tau Proteins","Neurodegenerative Diseases","Protein Transport","Microtubule-Organizing Center","Ubiquitin-Protein Ligases","alpha-Synuclein","Ubiquitination","Proteolysis","Protein Interaction Maps","Mitophagy"],"keywords":["Aggresome","HDAC6","Autophagy","Biology","Cell biology","Histone deacetylase","Protein aggregation","Ubiquitin","Histone","Genetics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T19:41:01.328812Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}