{"doi":"10.1089/crispr.2023.0048","title":"A Fluorescent Reporter Mouse for <i>In Vivo</i> Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors","abstract":"CRISPR-based genome-editing technologies, including nuclease editing, base editing, and prime editing, have recently revolutionized the development of therapeutics targeting disease-causing mutations. To advance the assessment and development of genome editing tools, a robust mouse model is valuable, particularly for evaluating in vivo activity and delivery strategies. In this study, we successfully generated a knock-in mouse line carrying the Traffic Light Reporter design known as TLR-multi-Cas variant 1 (TLR-MCV1). We comprehensively validated the functionality of this mouse model for both in vitro and in vivo nuclease and prime editing. The TLR-MCV1 reporter mouse represents a versatile and powerful tool for expediting the development of editing technologies and their therapeutic applications.","journal":"The CRISPR Journal","year":2023,"id":354542,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.939,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":363073,"name":"Suet‐Yan Kwan","orcid":null,"position":1,"is_corresponding":false},{"id":620177,"name":"Aamir Mir","orcid":"0000-0003-0144-3914","position":2,"is_corresponding":false},{"id":362072,"name":"Max D. Hazeltine","orcid":"0000-0002-0438-8626","position":3,"is_corresponding":false},{"id":625818,"name":"Minwook Shin","orcid":"0000-0003-0496-5873","position":4,"is_corresponding":false},{"id":362071,"name":"Shun‐Qing Liang","orcid":"0000-0003-4664-6029","position":5,"is_corresponding":false},{"id":889767,"name":"Io Long Chan","orcid":null,"position":6,"is_corresponding":false},{"id":268632,"name":"Karen Kelly","orcid":"0000-0002-2235-6636","position":7,"is_corresponding":false},{"id":563089,"name":"Krishna S. Ghanta","orcid":"0000-0001-7502-3141","position":8,"is_corresponding":false},{"id":1025812,"name":"Nicholas Gaston","orcid":"0000-0002-3862-9002","position":9,"is_corresponding":false},{"id":276606,"name":"Yueying Cao","orcid":null,"position":10,"is_corresponding":false},{"id":344875,"name":"Jun Xie","orcid":"0000-0001-9565-1567","position":11,"is_corresponding":false},{"id":226490,"name":"Guangping Gao","orcid":"0000-0003-0097-9012","position":12,"is_corresponding":false},{"id":265835,"name":"Wen Xue","orcid":"0000-0002-9797-8042","position":13,"is_corresponding":false},{"id":254500,"name":"Erik J. Sontheimer","orcid":"0000-0002-0881-0310","position":14,"is_corresponding":false},{"id":348431,"name":"Jonathan K. Watts","orcid":"0000-0001-5706-1734","position":15,"is_corresponding":false},{"id":633971,"name":"Zexiang Chen","orcid":"0000-0002-1584-2417","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-19T01:13:11.976628Z","pmid":"38108517","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}