{"doi":"10.1089/chi.2024.0248","title":"High BMI z-Scores from Different Growth References Are Not Comparable: An Example from a Weight Management Trial with an Anti-Obesity Medication in Pubertal Adolescents with Obesity","abstract":"Background: The BMI z-score is a standardized measure of weight status and weight change in children and adolescents. BMI z-scores from various growth references are often considered comparable, and differences among them are underappreciated. Methods: This study reanalyzed data from a weight management clinical study of liraglutide in pubertal adolescents with obesity using growth references from CDC 2000, CDC Extended, World Health Organization (WHO), and International Obesity Task Force. Results: BMI z-score treatment differences varied 2-fold from −0.13 (CDC 2000) to −0.26 (WHO) overall and varied almost 4-fold from −0.05 (CDC 2000) to −0.19 (WHO) among adolescents with high baseline BMI z-score. Conclusions: Depending upon the growth reference used, BMI z-score endpoints can produce highly variable treatment estimates and alter interpretations of clinical meaningfulness. BMI z-scores cited without the associated growth reference cannot be accurately interpreted.","journal":"Childhood Obesity","year":2024,"id":480679,"datarank":0.11230975963191943,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.008337682547927617,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.008337682547927617,"corpus_percentile":27.956989247311828,"corpus_rank":9314,"citation_count":1,"citer_count":1,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.646,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":40906,"name":"Cynthia L. Ogden","orcid":"0000-0003-1147-7157","position":1,"is_corresponding":false},{"id":303652,"name":"David S. Freedman","orcid":"0000-0001-8014-0289","position":2,"is_corresponding":false},{"id":1320536,"name":"Kushal Sahu","orcid":null,"position":3,"is_corresponding":false},{"id":1049053,"name":"Paula M. Hale","orcid":null,"position":4,"is_corresponding":false},{"id":1049054,"name":"Rashmi Mamadi","orcid":null,"position":5,"is_corresponding":false},{"id":245454,"name":"Aaron S. Kelly","orcid":"0000-0001-8530-107X","position":6,"is_corresponding":false},{"id":303653,"name":"Craig M. Hales","orcid":"0000-0002-2355-1177","position":0,"is_corresponding":true}],"reference_count":9,"raw_metadata":null,"created_at":"2026-07-19T02:07:02.142014Z","pmid":"38995874","pmcid":"PMC12422332","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}