{"doi":"10.1089/can.2022.0308","title":"Sexually Dimorphic Adolescent Trajectories of Prefrontal Endocannabinoid Synaptic Plasticity Equalize in Adulthood, Reflected by Endocannabinoid System Gene Expression","abstract":"Introduction: How sex influences prefrontal cortexes (PFCs) synaptic development through adolescence remains unclear. Materials and Methods: In this study we describe sex-specific cellular and synaptic trajectories in the rat PFC from adolescence to adulthood. Results: The excitability of PFC layer 5 pyramidal neurons was lower in adult females compared with other developmental stages. The developmental course of endocannabinoid-mediated long-term depression (eCB-LTD) was sexually dimorphic, unlike long-term potentiation or mGluR3-LTD. eCB-LTD was expressed in juvenile females but appeared only at puberty in males. Endovanilloid TRPV1R or eCB receptors were engaged during LTD in a sequential and sexually dimorphic manner. Gene expression of the eCB/vanilloid systems was sequential and sex specific. LTD-incompetent juvenile males had elevated expression levels of the CB1R-interacting inhibitory protein cannabinoid receptor interacting protein 1a and of the 2-arachidonoylglycerol-degrading enzyme ABHD6. Pharmacological inhibition of ABHD6 or MAGL enabled LTD in young males, whereas inhibition of anandamide degradation was ineffective. Conclusions: These results reveal sex differences in the maturational trajectories of the rat PFC.","journal":"Cannabis and Cannabinoid Research","year":2023,"id":337115,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9298,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":560657,"name":"Anissa Bara","orcid":"0000-0002-5721-2675","position":1,"is_corresponding":false},{"id":1068998,"name":"Michelle N. Murphy Green","orcid":null,"position":2,"is_corresponding":false},{"id":561276,"name":"Antonia Manduca","orcid":null,"position":3,"is_corresponding":false},{"id":749804,"name":"Jim Wager‐Miller","orcid":"0000-0001-9257-3057","position":4,"is_corresponding":false},{"id":459355,"name":"Milene Borsoï","orcid":"0000-0001-7199-6835","position":5,"is_corresponding":false},{"id":560658,"name":"Olivier Lassalle","orcid":"0000-0002-8523-1988","position":6,"is_corresponding":false},{"id":500780,"name":"Anne‐Laure Pélissier‐Alicot","orcid":"0000-0002-2466-6750","position":7,"is_corresponding":false},{"id":821700,"name":"Pascale Chavis","orcid":"0000-0002-3038-1014","position":8,"is_corresponding":false},{"id":227564,"name":"Ken Mackie","orcid":"0000-0001-8501-6199","position":9,"is_corresponding":false},{"id":459356,"name":"Olivier J. Manzoni","orcid":"0000-0002-5579-6208","position":10,"is_corresponding":false},{"id":561275,"name":"Axel Bernabeu","orcid":null,"position":0,"is_corresponding":true}],"reference_count":61,"raw_metadata":null,"created_at":"2026-07-19T01:10:26.690308Z","pmid":"37015060","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}