{"doi":"10.1089/ars.2017.7290","title":"The Role of Sirtuins in Antioxidant and Redox Signaling","abstract":"<jats:sec>\n                    <jats:title>Significance:</jats:title>\n                    <jats:p>Antioxidant and redox signaling (ARS) events are regulated by critical molecules that modulate antioxidants, reactive oxygen species (ROS) or reactive nitrogen species (RNS), and/or oxidative stress within the cell. Imbalances in these molecules can disturb cellular functions to become pathogenic. Sirtuins serve as important regulators of ARS in cells.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Recent Advances:</jats:title>\n                    <jats:p>Sirtuins (SIRTs 1–7) are a family of nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylases with the ability to deacetylate histone and nonhistone targets. Recent studies show that sirtuins modulate the regulation of a variety of cellular processes associated with ARS. SIRT1, SIRT3, and SIRT5 protect the cell from ROS, and SIRT2, SIRT6, and SIRT7 modulate key oxidative stress genes and mechanisms. Interestingly, SIRT4 has been shown to induce ROS production and has antioxidative roles as well.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Critical Issues:</jats:title>\n                    <jats:p>A complete understanding of the roles of sirtuins in redox homeostasis of the cell is very important to understand the normal functioning as well as pathological manifestations. In this review, we have provided a critical discussion on the role of sirtuins in the regulation of ARS. We have also discussed mechanistic interactions among different sirtuins. Indeed, a complete understanding of sirtuin biology could be critical at multiple fronts.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Future Directions:</jats:title>\n                    <jats:p>\n                      Sirtuins are emerging to be important in normal mammalian physiology and in a variety of oxidative stress-mediated pathological situations. Studies are needed to dissect the mechanisms of sirtuins in maintaining redox homeostasis. Efforts are also required to assess the targetability of sirtuins in the management of redox-regulated diseases.\n                      <jats:italic toggle=\"yes\">Antioxid. Redox Signal</jats:italic>\n                      . 28, 643–661.\n                    </jats:p>\n                  </jats:sec>","journal":"Antioxidants &amp; Redox Signaling","year":2018,"id":15166,"datarank":8.497382243552043,"base_score":6.697034247666484,"endowment":6.697034247666484,"self_citation_contribution":1.0045551371499728,"citation_network_contribution":7.49282710640207,"self_endowment_contribution":1.0045551371499728,"citer_contribution":7.49282710640207,"corpus_percentile":null,"corpus_rank":null,"citation_count":809,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":25,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":116797,"name":"Gagan Chhabra","orcid":null,"position":1,"is_corresponding":false},{"id":116798,"name":"Mary Ann Ndiaye","orcid":null,"position":2,"is_corresponding":false},{"id":116799,"name":"Liz Mariely Garcia-Peterson","orcid":null,"position":3,"is_corresponding":false},{"id":116800,"name":"Nicholas J. Mack","orcid":null,"position":4,"is_corresponding":false},{"id":116801,"name":"Nihal Ahmad","orcid":null,"position":5,"is_corresponding":false},{"id":116796,"name":"Chandra K. Singh","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":6.697034247666484,"endowment":6.697034247666484,"datacite_reuse_total":25,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28891317","pmcid":"PMC5824489","openalex_id":"https://openalex.org/W2756208820","authors":[],"funders":[{"funder_name":"CSRD VA","grant_id":"I01 CX001441","title":null},{"funder_name":"NCI NIH HHS","grant_id":"R01 CA176748","title":null},{"funder_name":"BLRD VA","grant_id":"I01 BX001008","title":null},{"funder_name":"NIAMS NIH HHS","grant_id":"R01 AR059130","title":null},{"funder_name":"BLRD VA","grant_id":"IK6 BX003780","title":null}],"total_grants":5,"fwci":18.8165,"citation_percentile":0.99695972,"influential_citations":20,"citation_trend":[{"year":2017,"count":1},{"year":2018,"count":13},{"year":2019,"count":33},{"year":2020,"count":79},{"year":2021,"count":100},{"year":2022,"count":155},{"year":2023,"count":120},{"year":2024,"count":156},{"year":2025,"count":110},{"year":2026,"count":41}],"oa_status":"bronze","license":"https://journals.sagepub.com/page/policies/text-and-data-mining-license","oa_locations":[{"url":"https://www.liebertpub.com/doi/pdf/10.1089/ars.2017.7290","host_type":"journal"},{"url":"https://www.liebertpub.com/doi/pdf/10.1089/ars.2017.7290","host_type":"BRONZE"},{"url":"https://www.liebertpub.com/doi/pdf/10.1089/ars.2017.7290","host_type":"publisher"},{"url":"https://journals.sagepub.com/doi/full-xml/10.1089/ars.2017.7290","host_type":"publisher"},{"url":"https://journals.sagepub.com/doi/pdf/10.1089/ars.2017.7290","host_type":"publisher"},{"url":"https://doi.org/10.1089/ars.2017.7290","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28891317","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5824489","host_type":"repository"}],"fields_of_study":["Sirtuins and Resveratrol in Medicine","PARP inhibition in cancer therapy","Biochemical and Molecular Research","Medicine","Biology","Environmental Science","Antioxidants","Histones","Humans","Mitochondria","Oxidation-Reduction","Oxidative Stress","Signal Transduction","Sirtuins"],"mesh_terms":["Antioxidants","Histones","Humans","Mitochondria","Oxidation-Reduction","Signal Transduction","Oxidative Stress","Sirtuins"],"keywords":["SIRT2","Sirtuin","SIRT6","SIRT3","Oxidative stress","Cell biology","Reactive oxygen species","Biology","Histone","NAD+ kinase","Nicotinamide adenine dinucleotide phosphate","Sirtuin 1","Cell signaling","Signal transduction","Biochemistry","Downregulation and upregulation","Oxidase test","Gene","Enzyme","Antioxidants","Sirtuins","Redox Signaling"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.6084/m9.figshare.21069480.v1","title":"Additional file 3 of Mitochondrial dysfunction is a key pathological driver of early stage Parkinson’s","publisher":"figshare","resource_type":"Presentation"},{"doi":"10.6084/m9.figshare.21069480","title":"Additional file 3 of Mitochondrial dysfunction is a key pathological driver of early stage Parkinson’s","publisher":"figshare","resource_type":"Presentation"},{"doi":"10.6084/m9.figshare.21069477.v1","title":"Additional file 2 of Mitochondrial dysfunction is a key pathological driver of early stage Parkinson’s","publisher":"figshare","resource_type":"Presentation"},{"doi":"10.6084/m9.figshare.21069477","title":"Additional file 2 of Mitochondrial dysfunction is a key pathological driver of early stage Parkinson’s","publisher":"figshare","resource_type":"Presentation"},{"doi":"10.6084/m9.figshare.21069474.v1","title":"Additional file 1 of Mitochondrial dysfunction is a key pathological driver of early stage Parkinson’s","publisher":"figshare","resource_type":"Presentation"},{"doi":"10.6084/m9.figshare.21069474","title":"Additional file 1 of Mitochondrial dysfunction is a key pathological driver of early stage Parkinson’s","publisher":"figshare","resource_type":"Presentation"},{"doi":"10.6084/m9.figshare.19947270.v1","title":"Additional file 1 of Platinum-induced mitochondrial OXPHOS contributes to cancer stem cell enrichment in ovarian cancer","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.19947270","title":"Additional file 1 of Platinum-induced mitochondrial OXPHOS contributes to cancer stem cell enrichment in ovarian cancer","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.19947273.v1","title":"Additional file 2 of Platinum-induced mitochondrial OXPHOS contributes to cancer stem cell enrichment in ovarian cancer","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.19947273","title":"Additional file 2 of Platinum-induced mitochondrial OXPHOS contributes to cancer stem cell enrichment in ovarian cancer","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.24892867","title":"Additional file 1 of SNP (A &gt; 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