{"doi":"10.1089/apc.2024.0043","title":"Disparities in Metabolic Syndrome and Neurocognitive Function Among Older Hispanics/Latinos with Human Immunodeficiency Virus","abstract":"Neurocognitive impairment and metabolic syndrome (MetS) are prevalent in persons with HIV (PWH). We examined disparities in HIV-associated neurocognitive function between Hispanic and non-Hispanic White older PWH, and the role of MetS in explaining these disparities. Participants included 116 community-dwelling PWH aged 50–75 years enrolled in a cohort study in southern California [58 Hispanic (53% Spanish speaking) and 58 age-comparable non-Hispanic White; overall group: age: M = 57.9, standard deviation (SD) = 5.7; education (years): M = 13, SD = 3.4; 83% male, 58% AIDS, 94% on antiretroviral therapy]. Global neurocognition was derived from T-scores adjusted for demographics (age, education, sex, ethnicity, language) on a battery of 10 cognitive tests. MetS was ascertained via standard criteria that considered central obesity, and fasting elevated triglycerides, low high-density lipoprotein cholesterol and elevated glucose, or medical treatment for these conditions. Covariates examined included sociodemographic, psychiatric, substance use and HIV disease characteristics. Compared with non-Hispanic Whites, Hispanics showed worse global neurocognitive function (Cohen's d = 0.56, p < 0.05) and had higher rates of MetS (38% vs. 56%, p < 0.05). A stepwise regression model including ethnicity and significant covariates showed Hispanic ethnicity was the sole significant predictor of worse global neurocognition (B = −3.82, SE = 1.27, p < 0.01). A model also including MetS showed that both Hispanic ethnicity (B = −3.39, SE = 1.31, p = 0.01) and MetS (B = −2.73, SE = 1.31, p = 0.04) were independently associated with worse neurocognition. In conclusion, findings indicate that increased MetS is associated with worse neurocognitive function in both Hispanic and non-Hispanic White older PWH, but does not explain neurocognitive disparities. MetS remains an important target for intervention efforts to ameliorate neurocognitive dysfunction among diverse older PWH.","journal":"AIDS Patient Care and STDs","year":2024,"id":463976,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.892,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":388851,"name":"Lily Kamalyan","orcid":"0000-0002-3099-0549","position":1,"is_corresponding":false},{"id":673793,"name":"Zvinka Z. 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Guareña","orcid":"0000-0002-4554-8876","position":9,"is_corresponding":false},{"id":1047310,"name":"Lilla Brody","orcid":"0000-0002-3860-688X","position":10,"is_corresponding":false},{"id":312162,"name":"Mariana Cherner","orcid":"0000-0002-5479-7401","position":11,"is_corresponding":false},{"id":371984,"name":"Ronald J. Ellis","orcid":"0000-0003-4931-752X","position":12,"is_corresponding":false},{"id":732327,"name":"María Luisa Zúñiga","orcid":"0000-0002-7324-3914","position":13,"is_corresponding":false},{"id":325848,"name":"Dan Mungas","orcid":"0000-0003-2035-7085","position":14,"is_corresponding":false},{"id":1291189,"name":"Raeanne C Moore","orcid":null,"position":15,"is_corresponding":false},{"id":69470,"name":"David J. Moore","orcid":"0000-0001-9699-318X","position":16,"is_corresponding":false},{"id":451150,"name":"Valerie Wojna","orcid":"0000-0002-4014-9921","position":17,"is_corresponding":false},{"id":19367,"name":"Rasheeda K. 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