{"doi":"10.1089/apc.2023.0028","title":"HIV Tissue Reservoirs: Current Advances in Research","abstract":"<jats:p>\n                    Acquired immunodeficiency syndrome (AIDS), caused by the human immunodeficiency virus (HIV), has become a heavy burden of disease and an important public health problem in the world. Although current antiretroviral therapy (ART) is effective at suppressing the virus in the blood, HIV still remains in two different types of reservoirs—the latently infected cells (represented by CD4\n                    <jats:sup>+</jats:sup>\n                    T cells) and the tissues containing those cells, which may block access to ART, HIV-neutralizing antibodies and latency-reversing agents. The latter is the focus of our review, as blood viral load drops below detectable levels after ART, a deeper and more systematic understanding of the HIV tissue reservoirs is imperative. In this review, we take the lymphoid system (including lymph nodes, gut-associated lymphoid tissue, spleen and bone marrow), nervous system, respiratory system, reproductive system (divided into male and female), urinary system as the order, focusing on the particularity and importance of each tissue in HIV infection, the infection target cell types of each tissue, the specific infection situation of each tissue quantified by HIV DNA or HIV RNA and the evidence of compartmentalization and pharmacokinetics. In summary, we found that the present state of HIV in different tissues has both similarities and differences. In the future, the therapeutic principle we need to follow is to respect the discrepancy on the basis of grasping the commonality. The measures taken to completely eliminate the virus in the whole body cannot be generalized. It is necessary to formulate personalized treatment strategies according to the different characteristics of the HIV in the various tissues, so as to realize the prospect of curing AIDS as soon as possible.\n                  </jats:p>","journal":"AIDS Patient Care and STDs","year":2023,"id":636178,"datarank":0.5456379239589579,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"self_citation_contribution":0.5456379239589579,"citation_network_contribution":0.0,"self_endowment_contribution":0.5456379239589579,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":37,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":618847,"name":"Bo Liu","orcid":"0000-0002-5008-296X","position":1,"is_corresponding":false},{"id":523544,"name":"Rui Ma","orcid":"0000-0001-7328-2924","position":2,"is_corresponding":false},{"id":516368,"name":"Qiang Zhang","orcid":"0000-0001-6203-0967","position":3,"is_corresponding":false},{"id":1650951,"name":"Kangpeng Li","orcid":"0009-0008-8406-5990","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"HIV Tissue Reservoirs: Current Advances in Research","abstract":"<jats:p>\n                    Acquired immunodeficiency syndrome (AIDS), caused by the human immunodeficiency virus (HIV), has become a heavy burden of disease and an important public health problem in the world. Although current antiretroviral therapy (ART) is effective at suppressing the virus in the blood, HIV still remains in two different types of reservoirs—the latently infected cells (represented by CD4\n                    <jats:sup>+</jats:sup>\n                    T cells) and the tissues containing those cells, which may block access to ART, HIV-neutralizing antibodies and latency-reversing agents. The latter is the focus of our review, as blood viral load drops below detectable levels after ART, a deeper and more systematic understanding of the HIV tissue reservoirs is imperative. In this review, we take the lymphoid system (including lymph nodes, gut-associated lymphoid tissue, spleen and bone marrow), nervous system, respiratory system, reproductive system (divided into male and female), urinary system as the order, focusing on the particularity and importance of each tissue in HIV infection, the infection target cell types of each tissue, the specific infection situation of each tissue quantified by HIV DNA or HIV RNA and the evidence of compartmentalization and pharmacokinetics. In summary, we found that the present state of HIV in different tissues has both similarities and differences. In the future, the therapeutic principle we need to follow is to respect the discrepancy on the basis of grasping the commonality. The measures taken to completely eliminate the virus in the whole body cannot be generalized. It is necessary to formulate personalized treatment strategies according to the different characteristics of the HIV in the various tissues, so as to realize the prospect of curing AIDS as soon as possible.\n                  </jats:p>","is_dataset_classified":null,"base_score":3.6109179126442243,"endowment":3.6109179126442243,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37184898","pmcid":null,"openalex_id":"https://openalex.org/W4376618806","authors":[],"funders":[],"total_grants":0,"fwci":4.4432,"citation_percentile":0.95167994,"influential_citations":0,"citation_trend":[{"year":2023,"count":3},{"year":2024,"count":16},{"year":2025,"count":12},{"year":2026,"count":5}],"oa_status":"closed","license":"https://journals.sagepub.com/page/policies/text-and-data-mining-license","oa_locations":[{"url":"https://journals.sagepub.com/doi/full-xml/10.1089/apc.2023.0028","host_type":"publisher"},{"url":"https://journals.sagepub.com/doi/pdf/10.1089/apc.2023.0028","host_type":"publisher"},{"url":"https://doi.org/10.1089/apc.2023.0028","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37184898","host_type":"repository"}],"fields_of_study":["HIV Research and Treatment","HIV-related health complications and treatments","HIV/AIDS Research and Interventions","Animals","Male","Female","Humans","Simian Acquired Immunodeficiency Syndrome","HIV Infections","Simian Immunodeficiency Virus","HIV","Acquired Immunodeficiency Syndrome","Virus Latency","Virus Replication","Macaca mulatta","Anti-Retroviral Agents","CD4-Positive T-Lymphocytes","Viral Load"],"mesh_terms":["Acquired Immunodeficiency Syndrome","Animals","Female","HIV","Humans","Macaca mulatta","Male","Virus Replication","Simian Immunodeficiency Virus","CD4-Positive T-Lymphocytes","HIV Infections","Simian Acquired Immunodeficiency Syndrome","Virus Latency","Viral Load","Anti-Retroviral Agents","Simian immunodeficiency virus"],"keywords":["Medicine","Lymphatic system","Immunology","Lymph","Virus","Virology","Pathology","Acquired immunodeficiency syndrome","HIV","Cellular Reservoir","Tissue Reservoir","Anatomical Reservoir"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.25963102.v1","title":"Additional file 1 of Characterization of the intestinal microbiota in MSM with HIV infection","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.25963102","title":"Additional file 1 of Characterization of the intestinal microbiota in MSM with HIV infection","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T16:30:52.057665Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}