{"doi":"10.1089/aid.2012.0209","title":"HIV Type 1 Origin and Transmission Dynamics Among Different Risk Groups in Sardinia: Molecular Epidemiology Within the Close Boundaries of an Italian Island","abstract":"<jats:p>\n                    In Italy, the HIV-1 epidemic is still mainly sustained by the subtype B genetic form, although other and novel subtypes and circulating recombinant forms (CRFs) have been reported. A total of 215 HIV-1\n                    <jats:italic toggle=\"yes\">pol</jats:italic>\n                    gene sequences were collected between 1992 and 2010. Multiple alignments spanning subtype-specific HIV-1 B\n                    <jats:italic toggle=\"yes\">pol</jats:italic>\n                    sequences were analyzed by Bayesian phylogenetic methods. Subtype B represented 90.7% (\n                    <jats:italic toggle=\"yes\">n</jats:italic>\n                    =195) of the sequences. Three main clusters were detected. The root of the tree dated to 1987. Most of the observed viral gene flow events occurred from heterosexual to intravenous drug users (IDUs). Phylogenetic and molecular clock analysis showed an early HIV-1 subtype B introduction in the mid-1980s and dissemination within local risk-specific clusters. This is the first study to describe in detail the HIV-1 molecular epidemiology in one of the largest islands in the European basin. The future potential of the Sardinian epidemic as a hub between Southern and Northern Europe has to been considered.\n                  </jats:p>","journal":"AIDS Research and Human Retroviruses","year":2013,"id":627387,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":51.7,"corpus_rank":6444,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1558682,"name":"Giordano Madeddu","orcid":null,"position":1,"is_corresponding":false},{"id":1114751,"name":"Alessandra Lo Presti","orcid":"0000-0001-7611-5021","position":2,"is_corresponding":false},{"id":722084,"name":"Eleonora Cella","orcid":"0000-0002-7870-9744","position":3,"is_corresponding":false},{"id":282145,"name":"Marta Giovanetti","orcid":"0000-0002-5849-7326","position":4,"is_corresponding":false},{"id":1623796,"name":"Carla Budroni","orcid":null,"position":5,"is_corresponding":false},{"id":1558684,"name":"Sergio Babudieri","orcid":null,"position":6,"is_corresponding":false},{"id":1623797,"name":"Maria Stella Mura","orcid":null,"position":7,"is_corresponding":false},{"id":121359,"name":"Gianguglielmo Zehender","orcid":null,"position":8,"is_corresponding":false},{"id":275663,"name":"Marco Salemi","orcid":"0000-0003-0136-2102","position":9,"is_corresponding":false},{"id":1256269,"name":"Massimo Ciccozzi","orcid":"0000-0003-3866-9239","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"HIV Type 1 Origin and Transmission Dynamics Among Different Risk Groups in Sardinia: Molecular Epidemiology Within the Close Boundaries of an Italian Island","abstract":"<jats:p>\n                    In Italy, the HIV-1 epidemic is still mainly sustained by the subtype B genetic form, although other and novel subtypes and circulating recombinant forms (CRFs) have been reported. A total of 215 HIV-1\n                    <jats:italic toggle=\"yes\">pol</jats:italic>\n                    gene sequences were collected between 1992 and 2010. Multiple alignments spanning subtype-specific HIV-1 B\n                    <jats:italic toggle=\"yes\">pol</jats:italic>\n                    sequences were analyzed by Bayesian phylogenetic methods. Subtype B represented 90.7% (\n                    <jats:italic toggle=\"yes\">n</jats:italic>\n                    =195) of the sequences. Three main clusters were detected. The root of the tree dated to 1987. Most of the observed viral gene flow events occurred from heterosexual to intravenous drug users (IDUs). Phylogenetic and molecular clock analysis showed an early HIV-1 subtype B introduction in the mid-1980s and dissemination within local risk-specific clusters. This is the first study to describe in detail the HIV-1 molecular epidemiology in one of the largest islands in the European basin. The future potential of the Sardinian epidemic as a hub between Southern and Northern Europe has to been considered.\n                  </jats:p>","is_dataset_classified":null,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22985362","pmcid":null,"openalex_id":"https://openalex.org/W2013751067","authors":[],"funders":[],"total_grants":0,"fwci":0.4973,"citation_percentile":0.60182371,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":1},{"year":2014,"count":1},{"year":2015,"count":1},{"year":2016,"count":1},{"year":2017,"count":2},{"year":2019,"count":1},{"year":2020,"count":2},{"year":2022,"count":1}],"oa_status":"closed","license":"https://journals.sagepub.com/page/policies/text-and-data-mining-license","oa_locations":[{"url":"https://journals.sagepub.com/doi/pdf/10.1089/aid.2012.0209","host_type":"publisher"},{"url":"https://journals.sagepub.com/doi/full-xml/10.1089/aid.2012.0209","host_type":"publisher"},{"url":"https://doi.org/10.1089/aid.2012.0209","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22985362","host_type":"repository"}],"fields_of_study":["HIV Research and Treatment","HIV/AIDS drug development and treatment","HIV/AIDS Research and Interventions"],"mesh_terms":["Adolescent","Adult","Aged","Child","Child, Preschool","Female","Humans","Infant","Infant, Newborn","Italy","Male","Middle Aged","HIV-1","HIV Infections","Cluster Analysis","Sequence Analysis, DNA","Molecular Epidemiology","pol Gene Products, Human Immunodeficiency Virus","Young Adult"],"keywords":["Phylogenetic tree","Molecular epidemiology","Molecular clock","Transmission (telecommunications)","Biology","Gene flow","Virology","Genetics","Phylogenetics","Epidemiology","Gene","Evolutionary biology","Genotype","Medicine","Genetic variation"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T17:20:24.125765Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}