{"doi":"10.1089/aid.2010.0284","title":"Presence of Drug Resistance Mutations Among Drug-Naive Patients in Morocco","abstract":null,"journal":"AIDS Research and Human Retroviruses","year":2011,"id":628292,"datarank":0.41588830833596724,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.0,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1626633,"name":"Patricia Recordon-Pinson","orcid":null,"position":1,"is_corresponding":false},{"id":1626634,"name":"Nabil Baba","orcid":null,"position":2,"is_corresponding":false},{"id":1626635,"name":"Omar Sedrati","orcid":null,"position":3,"is_corresponding":false},{"id":1626636,"name":"Saad Mrani","orcid":null,"position":4,"is_corresponding":false},{"id":36904,"name":"Hervé Fleury","orcid":"0000-0002-5318-489X","position":5,"is_corresponding":false},{"id":1626632,"name":"Hicham El Annaz","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Presence of Drug Resistance Mutations Among Drug-Naive Patients in Morocco","abstract":"The aim of the present study was to determine viral subtypes and resistance mutations to antiretroviral treatment (ART) in HIV-1-infected treatment-naive patients from Rabat, Morocco during the period 2005-2009. The protease and reverse transcriptase (RT) genes were sequenced, the phylogenetic trees were inferred, and the resistance-associated mutations to NRTIs, NNRTIs, and PIs were recorded according to the international list of surveillance drug resistance mutations (SDRMs). The viral subtypes were subtype B (74%), CRF02_AG (15%), A1 (6%), C (2%), F1 (1%), CRF09 (1%), and CRF25_cpx (1%). The presence of DRMs was found in four (5.06%) of 91 patients; resistance mutations to NRTIs were M184V and T215I/S revertant mutations; resistance to NNRTIs was associated with K103N and resistance to PIs with V82A. These findings have relevant implications for the local molecular mapping of HIV-1 and future ART surveillance studies in the region.","is_dataset_classified":null,"base_score":2.772588722239781,"endowment":2.772588722239781,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21087198","pmcid":null,"openalex_id":"https://openalex.org/W2008775144","authors":[],"funders":[],"total_grants":0,"fwci":1.0356,"citation_percentile":0.7402515,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2013,"count":2},{"year":2014,"count":1},{"year":2015,"count":1},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2021,"count":2},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://www.liebertpub.com/doi/pdf/10.1089/aid.2010.0284","host_type":"publisher"},{"url":"https://doi.org/10.1089/aid.2010.0284","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21087198","host_type":"repository"},{"url":"https://hal.science/hal-00675732","host_type":"repository"}],"fields_of_study":["HIV/AIDS drug development and treatment","HIV Research and Treatment","HIV/AIDS Research and Interventions"],"mesh_terms":["Adult","Female","Genotype","Humans","Middle Aged","Morocco","Mutation","Phylogeny","Retrospective Studies","RNA, Viral","HIV-1","HIV Infections","Polymerase Chain Reaction","DNA Fingerprinting","HIV Protease","Sequence Analysis, DNA","Anti-HIV Agents","Viral Load","Antiretroviral Therapy, Highly Active","Drug Resistance, Viral","HIV Reverse Transcriptase"],"keywords":["Resistance mutation","Drug resistance","Virology","Reverse transcriptase","Mutation","Biology","Protease","HIV drug resistance","Gene","Protease inhibitor (pharmacology)","Human immunodeficiency virus (HIV)","Genetics","Polymerase chain reaction","Viral load","Antiretroviral therapy","Enzyme"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T12:43:28.329744Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}