{"doi":"10.1089/088922200309160","title":"Subtype-Specific Sequence Variation of the HIV Type 1 Long Terminal Repeat and Primer-Binding Site","abstract":null,"journal":"AIDS Research and Human Retroviruses","year":2000,"id":47525,"datarank":2.4804412720370483,"base_score":3.9889840465642745,"endowment":3.9889840465642745,"self_citation_contribution":0.5983476069846413,"citation_network_contribution":1.882093665052407,"self_endowment_contribution":0.5983476069846413,"citer_contribution":1.882093665052407,"corpus_percentile":null,"corpus_rank":null,"citation_count":53,"citer_count":42,"citers_with_citation_signal":34,"citers_with_endowment":34,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":219895,"name":"Anthony De Ronde","orcid":null,"position":1,"is_corresponding":false},{"id":219896,"name":"Benjamin Berkhout","orcid":null,"position":2,"is_corresponding":false},{"id":172439,"name":"Marion Cornelissen","orcid":null,"position":3,"is_corresponding":false},{"id":219897,"name":"Karin H.M. Van Der Horn","orcid":null,"position":4,"is_corresponding":false},{"id":219898,"name":"Audrey M. Van Der Schoot","orcid":null,"position":5,"is_corresponding":false},{"id":219899,"name":"Frank De Wolf","orcid":null,"position":6,"is_corresponding":false},{"id":219900,"name":"Vladimir V. Lukashov","orcid":null,"position":7,"is_corresponding":false},{"id":219901,"name":"Jaap Goudsmit","orcid":null,"position":8,"is_corresponding":false},{"id":219894,"name":"Michel P. De Baar","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Subtype-Specific Sequence Variation of the HIV Type 1 Long Terminal Repeat and Primer-Binding Site","abstract":"We studied sequence differences in regulatory elements of the long terminal repeat (LTR) and primer-binding site (PBS) among various human immunodeficiency virus type 1 (HIV-1) subtypes. Phylogenetic sequence analysis of a fragment of 729 base pairs (bp) covering the Gag-coding region for half of p24 and all of p17 revealed the gag subtype of all 60 viruses included in the study: A (n = 20), B (n = 12), C (n = 7), D (n = 10), E (n = 3), F (n = 4), G (n = 3), and H (n = 1). The subtype was also determined by analysis of a 689-bp fragment comprising the LTR and the PBS motif. Comparison of the LTR versus gag sequences showed a mosaic genome for seven isolates. After analysis of all sequences, we could describe subtype-specific differences in sequences encompassing the regulatory elements of the LTR and the PBS motif.","is_dataset_classified":null,"base_score":3.9889840465642745,"endowment":3.9889840465642745,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"10772536","pmcid":null,"openalex_id":"https://openalex.org/W2178513559","authors":[],"funders":[],"total_grants":0,"fwci":1.0581,"citation_percentile":0.73248744,"influential_citations":3,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":4},{"year":2014,"count":4},{"year":2016,"count":1},{"year":2018,"count":3},{"year":2020,"count":4},{"year":2021,"count":1},{"year":2022,"count":1},{"year":2023,"count":5},{"year":2024,"count":3}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://www.liebertpub.com/doi/pdf/10.1089/088922200309160","host_type":"publisher"},{"url":"https://doi.org/10.1089/088922200309160","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/10772536","host_type":"repository"},{"url":"https://pure.amsterdamumc.nl/en/publications/4b458d23-265b-4fc9-8621-056fbebd0650","host_type":"repository"},{"url":"https://pure.amc.nl/en/publications/subtypespecific-sequence-variation-of-the-hiv-type-1-long-terminal-repeat-and-primerbinding-site(71d8aa53-21e2-484a-9d6b-14e3297c7bb7).html","host_type":"repository"}],"fields_of_study":["HIV Research and Treatment","HIV/AIDS drug development and treatment","Plant Virus Research Studies","Biology","Medicine","Base Sequence","Binding Sites","Consensus Sequence","Genes, Viral","Genes, gag","HIV Infections","HIV-1","Humans","Molecular Sequence Data","Phylogeny","Sequence Alignment","Terminal Repeat Sequences"],"mesh_terms":["Base Sequence","Binding Sites","Genes, Viral","Humans","Molecular Sequence Data","Phylogeny","HIV-1","HIV Infections","Genes, gag","Consensus Sequence","Sequence Alignment","Terminal Repeat Sequences"],"keywords":["Primer binding site","Long terminal repeat","Biology","Phylogenetic tree","Primer (cosmetics)","Group-specific antigen","Genetics","Coding region","Sequence analysis","Genome","Molecular biology","Virology","Human immunodeficiency virus (HIV)","Sequence (biology)","Virus","Reverse transcriptase","Gene","Polymerase chain reaction","Chemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-18T19:14:17.819413Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}