{"doi":"10.1088/1748-605x/ad2e0f","title":"Oxidized alginate-gelatin (ADA-GEL)/silk fibroin/Cu-Ag doped mesoporous bioactive glass nanoparticle-based hydrogels for potential wound care treatments","abstract":"Abstract The present work focuses on developing 5% w/v oxidized alginate (alginate di aldehyde, ADA)-7.5% w/v gelatin (GEL) hydrogels incorporating 0.25% w/v silk fibroin (SF) and loaded with 0.3% w/v Cu-Ag doped mesoporous bioactive glass nanoparticles (Cu-Ag MBGNs). The microstructural, mechanical, and biological properties of the composite hydrogels were characterized in detail. The porous microstructure of the developed ADA-GEL based hydrogels was confirmed by scanning electron microscopy, while the presence of Cu-Ag MBGNs in the synthesized hydrogels was determined using energy dispersive x-ray spectroscopy. The incorporation of 0.3% w/v Cu-Ag MBGNs reduced the mechanical properties of the synthesized hydrogels, as investigated using micro-tensile testing. The synthesized ADA-GEL loaded with 0.25% w/v SF and 0.3% w/v Cu-Ag MBGNs showed a potent antibacterial effect against Escherichia coli and Staphylococcus aureus . Cellular studies using the NIH3T3-E1 fibroblast cell line confirmed that ADA-GEL films incorporated with 0.3% w/v Cu-Ag MBGNs exhibited promising cellular viability as compared to pure ADA-GEL (determined by WST-8 assay). The addition of SF improved the biocompatibility, degradation rate, moisturizing effects, and stretchability of the developed hydrogels, as determined in vitro . Such multimaterial hydrogels can stimulate angiogenesis and exhibit desirable antibacterial properties. Therefore further ( in vivo ) tests are justified to assess the hydrogels’ potential for wound dressing and skin tissue healing applications.","journal":"Biomedical Materials","year":2024,"id":433711,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9576,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1239942,"name":"Arooba Nazneen","orcid":null,"position":1,"is_corresponding":false},{"id":1239439,"name":"Muhammad Awais","orcid":"0000-0002-7338-8961","position":2,"is_corresponding":false},{"id":231915,"name":"Rabia Hussain","orcid":"0000-0001-8183-0855","position":3,"is_corresponding":false},{"id":1239440,"name":"Ahmad Khan","orcid":"0000-0001-8791-8866","position":4,"is_corresponding":false},{"id":1239441,"name":"Muhammad Irfan","orcid":"0000-0001-5611-489X","position":5,"is_corresponding":false},{"id":1239442,"name":"Egemen Avcu","orcid":"0000-0002-3244-1316","position":6,"is_corresponding":false},{"id":1239443,"name":"Muhammad Atiq Ur Rehman","orcid":"0000-0001-5201-973X","position":7,"is_corresponding":false},{"id":656607,"name":"Aldo R. Boccaccini","orcid":"0000-0002-7377-2955","position":8,"is_corresponding":false},{"id":1239438,"name":"Memoona Akhtar","orcid":"0000-0003-0570-9644","position":0,"is_corresponding":true}],"reference_count":85,"raw_metadata":null,"created_at":"2026-07-19T01:59:49.434790Z","pmid":"38417147","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}