{"doi":"10.1088/1741-2552/ada0eb","title":"Longitudinal changes in electrophysiology and widefield calcium imaging following electrode implantation","abstract":"Abstract Objective . Intracortical microelectrode arrays often fail to deliver reliable signal quality over chronic recordings, and the effect of an implanted recording array on local neural circuits is not completely understood. Approach . In this work we examined the degree of correlation and the spatial dependence of that relationship between widefield calcium imaging and electrophysiology in awake mice from 4 to 44 d post-implantation. Both correlation maps and spike-triggered averaging (STA) are used to characterize the relationship. Main results . We find that calcium imaging and electrophysiological signal are highly correlated in all animals, however, spatial variability in the correlation is affected by inherent correlation in the calcium imaging signal. Some animals exhibit a high degree of apparent neuronal synchrony in the vicinity of the probe at 4 d, while more diversity of response is detected at later time points. Significance . Degree of synchrony appears to be related to the acute injury response to the implanted electrode, with later time points displaying less synchrony. STA may be used to uncover the diverse cortical connections of spiking units.","journal":"Journal of Neural Engineering","year":2024,"id":482695,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.95,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":330141,"name":"James R. Eles","orcid":null,"position":1,"is_corresponding":false},{"id":1323217,"name":"Xin Zheng","orcid":"0000-0002-7108-0613","position":2,"is_corresponding":false},{"id":328509,"name":"Takashi D.Y. Kozai","orcid":"0000-0002-2507-3295","position":3,"is_corresponding":false},{"id":308471,"name":"Xinyan Tracy Cui","orcid":"0000-0002-0470-2005","position":4,"is_corresponding":false},{"id":336924,"name":"Alberto L. Vazquez","orcid":"0000-0002-5105-9825","position":5,"is_corresponding":false},{"id":1323216,"name":"Carol A. Robbins","orcid":"0000-0002-7184-9533","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-19T02:07:18.280369Z","pmid":"39693772","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}