{"doi":"10.1088/1741-2552/ace4f4","title":"Multi-scale multi-physics model of brain interstitial water flux by transcranial Direct Current Stimulation","abstract":"Abstract Objective . Transcranial direct current stimulation (tDCS) generates sustained electric fields in the brain, that may be amplified when crossing capillary walls (across blood-brain barrier, BBB). Electric fields across the BBB may generate fluid flow by electroosmosis. We consider that tDCS may thus enhance interstitial fluid flow. Approach . We developed a modeling pipeline novel in both (1) spanning the mm (head), μ m (capillary network), and then nm (down to BBB tight junction (TJ)) scales; and (2) coupling electric current flow to fluid current flow across these scales. Electroosmotic coupling was parametrized based on prior measures of fluid flow across isolated BBB layers. Electric field amplification across the BBB in a realistic capillary network was converted to volumetric fluid exchange. Main results . The ultrastructure of the BBB results in peak electric fields (per mA of applied current) of 32–63 <mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" overflow=\"scroll\"> <mml:mrow> <mml:mtext>V</mml:mtext> </mml:mrow> <mml:mrow> <mml:msup> <mml:mrow> <mml:mtext>m</mml:mtext> </mml:mrow> <mml:mrow> <mml:mo>−</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> </mml:math> across capillary wall and &gt;1150 <mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" overflow=\"scroll\"> <mml:mrow> <mml:mtext>V</mml:mtext> </mml:mrow> <mml:mrow> <mml:msup> <mml:mrow> <mml:mtext>m</mml:mtext> </mml:mrow> <mml:mrow> <mml:mo>−</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> </mml:math> in TJs (contrasted with 0.3 <mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" overflow=\"scroll\"> <mml:mrow> <mml:mtext>V</mml:mtext> </mml:mrow> <mml:mrow> <mml:msup> <mml:mrow> <mml:mtext>m</mml:mtext> </mml:mrow> <mml:mrow> <mml:mo>−</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> </mml:math> in parenchyma). Based on an electroosmotic coupling of 1.0 × 10 −9 – 5.6 × 10 −10 <mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" overflow=\"scroll\"> <mml:mfrac> <mml:mrow> <mml:mrow> <mml:msup> <mml:mrow> <mml:mtext>m</mml:mtext> </mml:mrow> <mml:mrow> <mml:mtext>3</mml:mtext> </mml:mrow> </mml:msup> </mml:mrow> <mml:mrow> <mml:msup> <mml:mrow> <mml:mtext>s</mml:mtext> </mml:mrow> <mml:mrow> <mml:mo>−</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> </mml:mrow> <mml:mrow> <mml:mrow> <mml:msup> <mml:mrow> <mml:mtext>m</mml:mtext> </mml:mrow> <mml:mrow> <mml:mtext>2</mml:mtext> </mml:mrow> </mml:msup> </mml:mrow> </mml:mrow> </mml:mfrac> </mml:math> per <mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" overflow=\"scroll\"> <mml:mrow> <mml:mtext>V</mml:mtext> </mml:mrow> <mml:mrow> <mml:msup> <mml:mrow> <mml:mtext>m</mml:mtext> </mml:mrow> <mml:mrow> <mml:mo>−</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> </mml:math> , peak water fluxes across the BBB are 2.44 × 10 −10 – 6.94 × 10 −10 <mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" overflow=\"scroll\"> <mml:mfrac> <mml:mrow> <mml:mrow> <mml:msup> <mml:mrow> <mml:mtext>m</mml:mtext> </mml:mrow> <mml:mrow> <mml:mtext>3</mml:mtext> </mml:mrow> </mml:msup> </mml:mrow> <mml:mrow> <mml:msup> <mml:mrow> <mml:mtext>s</mml:mtext> </mml:mrow> <mml:mrow> <mml:mo>−</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> </mml:mrow> <mml:mrow> <mml:mrow> <mml:msup> <mml:mrow> <mml:mtext>m</mml:mtext> </mml:mrow> <mml:mrow> <mml:mtext>2</mml:mtext> </mml:mrow> </mml:msup> </mml:mrow> </mml:mrow> </mml:mfrac> </mml:math> , with a peak 1.5 × 10 −4 – 5.6 × 10 −4 <mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" overflow=\"scroll\"> <mml:mfrac> <mml:mrow> <mml:mrow> <mml:msup> <","journal":"Journal of Neural Engineering","year":2023,"id":369340,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9076,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":627416,"name":"Cynthia Poon","orcid":"0000-0001-9012-9809","position":1,"is_corresponding":false},{"id":302927,"name":"Limary M. 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