{"doi":"10.1088/1741-2552/abb63a","title":"Acoustoelectric imaging of deep dipoles in a human head phantom for guiding treatment of epilepsy","abstract":"OBJECTIVE: This study employs a human head model with real skull to demonstrate the feasibility of transcranial acoustoelectric brain imaging (tABI) as a new modality for electrical mapping of deep dipole sources during treatment of epilepsy with much better resolution and accuracy than conventional mapping methods. APPROACH: This technique exploits an interaction between a focused ultrasound (US) beam and tissue resistivity to localize current source densities as deep as 63 mm at high spatial resolution (1 to 4 mm) and resolve fast time-varying currents with sub-ms precision. MAIN RESULTS: Detection thresholds through a thick segment of the human skull at biologically safe US intensities was below 0.5 mA and within range of strong currents generated by the human brain. SIGNIFICANCE: This work suggests that 4D tABI may emerge as a revolutionary modality for real-time high-resolution mapping of neuronal currents for the purpose of monitoring, staging, and guiding treatment of epilepsy and other brain disorders characterized by abnormal rhythms.","journal":"Journal of Neural Engineering","year":2020,"id":102577,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9621,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":371277,"name":"Chet Preston","orcid":"0000-0002-4998-0308","position":1,"is_corresponding":false},{"id":501936,"name":"Alex Alvarez","orcid":null,"position":2,"is_corresponding":false},{"id":500815,"name":"Tushar Kanti Bera","orcid":"0000-0002-1912-4551","position":3,"is_corresponding":false},{"id":500816,"name":"Yexian Qin","orcid":"0000-0002-7222-042X","position":4,"is_corresponding":false},{"id":500817,"name":"Martin Weinand","orcid":"0000-0002-6913-8134","position":5,"is_corresponding":false},{"id":490455,"name":"Willard S. Kasoff","orcid":"0000-0003-3665-5554","position":6,"is_corresponding":false},{"id":372761,"name":"Russell S. Witte","orcid":null,"position":7,"is_corresponding":false},{"id":491313,"name":"Andres Barragan","orcid":null,"position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":null,"created_at":"2026-07-18T22:41:53.173268Z","pmid":"33124600","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}