{"doi":"10.1088/1361-6560/ada084","title":"High spatial resolution PET detectors based on 10 mm × 10 mm\n\t\t\t\t\tlinearly-graded SiPMs and 0.5 mm pitch LYSO arrays","abstract":"<jats:title>Abstract</jats:title>\n               <jats:p>\n                  <jats:italic>Objective</jats:italic>. Position-sensitive silicon photomultipliers\n\t\t\t\t\t(PS-SiPMs) are promising photodetectors for ultra-high spatial resolution\n\t\t\t\t\tsmall-animal positron emission tomography (PET) scanners. This paper evaluated\n\t\t\t\t\tthe performance of the latest generation of linearly-graded SiPMs (LG-SiPMs), a\n\t\t\t\t\ttype of PS-SiPM, for ultra-high spatial resolution PET applications using LYSO\n\t\t\t\t\tarrays from two vendors. <jats:italic>Approach</jats:italic>. Two dual-ended readout\n\t\t\t\t\tdetectors were developed by coupling LG-SiPMs to both ends of the two LYSO\n\t\t\t\t\tarrays. Each LG-SiPM has an active area of 9.8 × 9.8 mm<jats:sup>2</jats:sup>. Both\n\t\t\t\t\tLYSO arrays consist of 20 × 20 arrays of 0.44 × 0.44 × 20\n\t\t\t\t\t\tmm<jats:sup>3</jats:sup> polished LYSOs with a pitch of 0.5 mm. The performance of the\n\t\t\t\t\ttwo detectors was compared in terms of flood histogram, energy resolution,\n\t\t\t\t\ttiming resolution, and depth-of-interaction (DOI) resolutions. <jats:italic>Main\n\t\t\t\t\t\tresults</jats:italic>. Flood histograms showed clear identification of all LYSO\n\t\t\t\t\telements except for some edge crystals due to the larger size of the LYSO arrays\n\t\t\t\t\tcompared to the active area of the LG-SiPMs and the misalignment between\n\t\t\t\t\tLG-SiPMs and LYSO arrays in the assembled detectors. At a bias voltage of 37.0\n\t\t\t\t\tV, the detectors utilizing the Tianle LYSO array and EBO LYSO array provided\n\t\t\t\t\tenergy resolutions of 17.5 ± 2.2 and 18.6 ± 2.0%, timing\n\t\t\t\t\tresolutions of 0.75 ± 0.03 and 0.78 ± 0.03 ns, and DOI resolutions\n\t\t\t\t\tof 2.16 ± 0.15 and 2.31 ± 0.12 mm, respectively.\n\t\t\t\t\t\t<jats:italic>Significance</jats:italic>. The results presented in this paper\n\t\t\t\t\tdemonstrate that the new generation LG-SiPMs are promising photodetectors for\n\t\t\t\t\tultra-high spatial resolution small-animal PET scanner applications.</jats:p>","journal":"Physics in Medicine &amp; Biology","year":2025,"id":656501,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1196826,"name":"H.B. Wang","orcid":"0009-0006-9182-9237","position":1,"is_corresponding":false},{"id":1034400,"name":"S. Merzi","orcid":"0000-0002-0512-2491","position":2,"is_corresponding":false},{"id":1713749,"name":"Giovanni Paternoster","orcid":null,"position":3,"is_corresponding":false},{"id":1713751,"name":"Alberto Gola","orcid":null,"position":4,"is_corresponding":false},{"id":256279,"name":"Jinyi Qi","orcid":"0000-0002-5428-0322","position":5,"is_corresponding":false},{"id":1713753,"name":"Simon R Cherry","orcid":null,"position":6,"is_corresponding":false},{"id":426566,"name":"Junwei Du","orcid":"0000-0002-1719-8266","position":7,"is_corresponding":false},{"id":1279695,"name":"Jiahao Xie","orcid":"0009-0005-2575-2027","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"High spatial resolution PET detectors based on 10 mm × 10 mm\n\t\t\t\t\tlinearly-graded SiPMs and 0.5 mm pitch LYSO arrays","abstract":"<jats:title>Abstract</jats:title>\n               <jats:p>\n                  <jats:italic>Objective</jats:italic>. Position-sensitive silicon photomultipliers\n\t\t\t\t\t(PS-SiPMs) are promising photodetectors for ultra-high spatial resolution\n\t\t\t\t\tsmall-animal positron emission tomography (PET) scanners. This paper evaluated\n\t\t\t\t\tthe performance of the latest generation of linearly-graded SiPMs (LG-SiPMs), a\n\t\t\t\t\ttype of PS-SiPM, for ultra-high spatial resolution PET applications using LYSO\n\t\t\t\t\tarrays from two vendors. <jats:italic>Approach</jats:italic>. Two dual-ended readout\n\t\t\t\t\tdetectors were developed by coupling LG-SiPMs to both ends of the two LYSO\n\t\t\t\t\tarrays. Each LG-SiPM has an active area of 9.8 × 9.8 mm<jats:sup>2</jats:sup>. Both\n\t\t\t\t\tLYSO arrays consist of 20 × 20 arrays of 0.44 × 0.44 × 20\n\t\t\t\t\t\tmm<jats:sup>3</jats:sup> polished LYSOs with a pitch of 0.5 mm. The performance of the\n\t\t\t\t\ttwo detectors was compared in terms of flood histogram, energy resolution,\n\t\t\t\t\ttiming resolution, and depth-of-interaction (DOI) resolutions. <jats:italic>Main\n\t\t\t\t\t\tresults</jats:italic>. Flood histograms showed clear identification of all LYSO\n\t\t\t\t\telements except for some edge crystals due to the larger size of the LYSO arrays\n\t\t\t\t\tcompared to the active area of the LG-SiPMs and the misalignment between\n\t\t\t\t\tLG-SiPMs and LYSO arrays in the assembled detectors. At a bias voltage of 37.0\n\t\t\t\t\tV, the detectors utilizing the Tianle LYSO array and EBO LYSO array provided\n\t\t\t\t\tenergy resolutions of 17.5 ± 2.2 and 18.6 ± 2.0%, timing\n\t\t\t\t\tresolutions of 0.75 ± 0.03 and 0.78 ± 0.03 ns, and DOI resolutions\n\t\t\t\t\tof 2.16 ± 0.15 and 2.31 ± 0.12 mm, respectively.\n\t\t\t\t\t\t<jats:italic>Significance</jats:italic>. The results presented in this paper\n\t\t\t\t\tdemonstrate that the new generation LG-SiPMs are promising photodetectors for\n\t\t\t\t\tultra-high spatial resolution small-animal PET scanner applications.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39689427","pmcid":"PMC12084082","openalex_id":null,"authors":[],"funders":[{"funder_name":"NIH","grant_id":"R01 EB031961","title":null}],"total_grants":1,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":null,"license":"https://iopscience.iop.org/info/page/text-and-data-mining","oa_locations":[{"url":"https://iopscience.iop.org/article/10.1088/1361-6560/ada084","host_type":"publisher"},{"url":"https://iopscience.iop.org/article/10.1088/1361-6560/ada084/pdf","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Animals","Silicon","Positron-Emission Tomography"],"keywords":["Resolution","PET","Doi","Lg-sipm","Ps-sipm"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T21:05:25.742408Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}