{"doi":"10.1086/386324","title":"Echinacea purpurea for Prevention of Experimental Rhinovirus Colds","abstract":null,"journal":"Clinical Infectious Diseases","year":2004,"id":670682,"datarank":0.637274286307404,"base_score":4.248495242049359,"endowment":4.248495242049359,"self_citation_contribution":0.637274286307404,"citation_network_contribution":0.0,"self_endowment_contribution":0.637274286307404,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":69,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1751923,"name":"L. P. Shah","orcid":null,"position":1,"is_corresponding":false},{"id":1751924,"name":"R. D. Gilbert","orcid":null,"position":2,"is_corresponding":false},{"id":1751925,"name":"T. W. Ritchey","orcid":null,"position":3,"is_corresponding":false},{"id":1751926,"name":"A. S. Monto","orcid":null,"position":4,"is_corresponding":false},{"id":1751922,"name":"S. J. Sperber","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Echinacea purpurea for Prevention of Experimental Rhinovirus Colds","abstract":"A randomized, double-blind, placebo-controlled clinical trial was conducted to evaluate the ability of Echinacea purpurea to prevent infection with rhinovirus type 39 (RV-39). Forty-eight previously healthy adults received echinacea or placebo, 2.5 mL 3 times per day, for 7 days before and 7 days after intranasal inoculation with RV-39. Symptoms were assessed to evaluate clinical illness. Viral culture and serologic studies were performed to evaluate the presence of rhinovirus infection. A total of 92% of echinacea recipients and 95% of placebo recipients were infected. Colds developed in 58% of echinacea recipients and 82% of placebo recipients (P=.114, by Fisher's exact test). Administration of echinacea before and after exposure to rhinovirus did not decrease the rate of infection; however, because of the small sample size, statistical hypothesis testing had relatively poor power to detect statistically significant differences in the frequency and severity of illness.","is_dataset_classified":null,"base_score":4.248495242049359,"endowment":4.248495242049359,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15156472","pmcid":"PMC7107999","openalex_id":"https://openalex.org/W1982980945","authors":[],"funders":[],"total_grants":0,"fwci":18.107,"citation_percentile":0.98959814,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":2},{"year":2014,"count":4},{"year":2015,"count":3},{"year":2016,"count":3},{"year":2017,"count":2},{"year":2018,"count":1},{"year":2019,"count":2},{"year":2020,"count":4},{"year":2021,"count":1},{"year":2022,"count":3},{"year":2023,"count":1},{"year":2024,"count":3},{"year":2025,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://academic.oup.com/cid/article-pdf/38/10/1367/6026054/38-10-1367.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1086/386324","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/15156472","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7107999","host_type":"repository"},{"url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.867.9738","host_type":""}],"fields_of_study":["Herbal Medicine Research Studies","Toxin Mechanisms and Immunotoxins","Complementary and Alternative Medicine Studies"],"mesh_terms":["Adolescent","Adult","Aged","Common Cold","Double-Blind Method","Drug Tolerance","Female","Humans","Male","Phytotherapy","Middle Aged","Plant Extracts","Plants, Medicinal","Random Allocation","Rhinovirus","Echinacea"],"keywords":["Rhinovirus","Echinacea (animal)","Medicine","Placebo","Common cold","Internal medicine","Randomized controlled trial","Traditional medicine","Immunology","Respiratory system","Pathology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-15T23:19:04.678255Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}