{"doi":"10.1086/318530","title":"Perinatal Transmission of Human Immunodeficiency Virus Type 1 by Pregnant Women with RNA Virus Loads &lt;1000 Copies/mL","abstract":"In a collaboration of 7 European and United States prospective studies, 44 cases of vertical human immunodeficiency virus type 1 (HIV-1) transmission were identified among 1202 women with RNA virus loads <1000 copies/mL at delivery or at the measurement closest to delivery. For mothers receiving antiretroviral treatment during pregnancy or at the time of delivery (or both), there was a 1.0% transmission rate (8 of 834; 95% confidence interval [CI], 0.4%-1.9%), compared with 9.8% (36 of 368; 95% CI, 7.0%-13.4%) for untreated mothers (risk ratio, 0.10; 95% CI, 0.05-0.21). In multivariate analysis adjusting for study, transmission was lower with antiretroviral treatment (odds ratio [OR], 0.10; P<.001), cesarean section (OR, 0.30; P=.022), greater birth weight (P=.003), and higher CD4 cell count (P=.039). In 12 of 44 cases, multiple RNA measurements were obtained during pregnancy or at the time of delivery or within 4 months after giving birth; in 10 of the 12 cases, the geometric mean virus load was >500 copies/mL. Perinatal HIV-1 transmission occurs in only 1% of treated women with RNA virus loads <1000 copies/mL and may be almost eliminated with antiretroviral prophylaxis accompanied by suppression of maternal viremia.","journal":"The Journal of Infectious Diseases","year":2001,"id":2099,"datarank":0.8910256879080649,"base_score":5.940171252720432,"endowment":5.940171252720432,"self_citation_contribution":0.8910256879080649,"citation_network_contribution":0.0,"self_endowment_contribution":0.8910256879080649,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":379,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0689,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2001-02-15","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":24184,"name":"Elaine J. Abrams","orcid":"0000-0001-7938-8981","position":1,"is_corresponding":false},{"id":24185,"name":"Arthur Ammann","orcid":null,"position":2,"is_corresponding":false},{"id":24186,"name":"Marc Bulterys","orcid":null,"position":3,"is_corresponding":false},{"id":24059,"name":"James J. Goedert","orcid":"0000-0001-6134-1472","position":4,"is_corresponding":false},{"id":24187,"name":"Linsay Gray","orcid":"0000-0002-6918-5037","position":5,"is_corresponding":false},{"id":24188,"name":"Bette T. Korber","orcid":null,"position":6,"is_corresponding":false},{"id":24189,"name":"Marie Jeanne Mayaux","orcid":null,"position":7,"is_corresponding":false},{"id":24190,"name":"Lynne M. Mofenson","orcid":null,"position":8,"is_corresponding":false},{"id":24191,"name":"Marie‐Louise Newell","orcid":"0000-0002-1074-7699","position":9,"is_corresponding":false},{"id":24192,"name":"David E. Shapiro","orcid":null,"position":10,"is_corresponding":false},{"id":24193,"name":"Jean Paul Teglas","orcid":null,"position":11,"is_corresponding":false},{"id":24194,"name":"Catherine M. Wilfert","orcid":null,"position":12,"is_corresponding":false},{"id":24195,"name":"A. J. Ammann","orcid":null,"position":13,"is_corresponding":false},{"id":24196,"name":"J. J. Goedert","orcid":null,"position":14,"is_corresponding":false},{"id":24197,"name":"Bette Korber","orcid":"0000-0002-2026-5757","position":15,"is_corresponding":false},{"id":24198,"name":"M. J. Mayaux","orcid":null,"position":16,"is_corresponding":false},{"id":24199,"name":"Lynne Mofenson","orcid":"0000-0002-2818-9808","position":17,"is_corresponding":false},{"id":24200,"name":"Jean‐Paul Teglas","orcid":null,"position":18,"is_corresponding":false},{"id":148,"name":"John P. A. Ioannidis","orcid":"0000-0003-3118-6859","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}