{"doi":"10.1086/315554","title":"Biology and Molecular Epidemiology of Diphtheria Toxin and the<i>tox</i>Gene","abstract":null,"journal":"The Journal of Infectious Diseases","year":2000,"id":688910,"datarank":0.8163626565782691,"base_score":5.442417710521793,"endowment":5.442417710521793,"self_citation_contribution":0.8163626565782691,"citation_network_contribution":0.0,"self_endowment_contribution":0.8163626565782691,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":230,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1799761,"name":"Randall K. Holmes","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Biology and Molecular Epidemiology of Diphtheria Toxin and the<i>tox</i>Gene","abstract":"Diphtheria toxin (DT) is an extracellular protein of Corynebacterium diphtheriae that inhibits protein synthesis and kills susceptible cells. The gene that encodes DT (tox) is present in some corynephages, and DT is only produced by C. diphtheriae isolates that harbor tox+ phages. The diphtheria toxin repressor (DtxR) is a global regulatory protein that uses Fe2+ as co-repressor. Holo-DtxR represses production of DT, corynebacterial siderophore, heme oxygenase, and several other proteins. Diagnostic tests for toxinogenicity of C. diphtheriae are based either on immunoassays or on bioassays for DT. Molecular analysis of tox and dtxR genes in recent clinical isolates of C. diphtheriae revealed several tox alleles that encode identical DT proteins and multiple dtxR alleles that encode five variants of DtxR protein. Therefore, recent clinical isolates of C. diphtheriae produce a single antigenic type of DT, and diphtheria toxoid continues to be an effective vaccine for immunization against diphtheria.","is_dataset_classified":null,"base_score":5.442417710521793,"endowment":5.442417710521793,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"10657208","pmcid":null,"openalex_id":"https://openalex.org/W1967073350","authors":[],"funders":[{"funder_name":"NIAID NIH HHS","grant_id":"AI-14107","title":null}],"total_grants":1,"fwci":1.692,"citation_percentile":0.83313441,"influential_citations":0,"citation_trend":[{"year":2012,"count":9},{"year":2013,"count":12},{"year":2014,"count":10},{"year":2015,"count":16},{"year":2016,"count":12},{"year":2017,"count":11},{"year":2018,"count":7},{"year":2019,"count":11},{"year":2020,"count":11},{"year":2021,"count":9},{"year":2022,"count":13},{"year":2023,"count":11},{"year":2024,"count":6},{"year":2025,"count":10},{"year":2026,"count":5}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://academic.oup.com/jid/article-pdf/181/Supplement_1/S156/11630452/181-Supplement_1-S156.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1086/315554","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/10657208","host_type":"repository"}],"fields_of_study":["Toxin Mechanisms and Immunotoxins","Diphtheria, Corynebacterium, and Tetanus","Clostridium difficile and Clostridium perfringens research","Bacterial Proteins","Corynebacterium diphtheriae","DNA-Binding Proteins","Diphtheria","Diphtheria Toxin","Genes, Bacterial","Humans","Molecular Epidemiology"],"mesh_terms":["Bacterial Proteins","Corynebacterium diphtheriae","Diphtheria","Diphtheria Toxin","DNA-Binding Proteins","Genes, Bacterial","Humans","Molecular Epidemiology"],"keywords":["Corynebacterium diphtheriae","Diphtheria toxin","Biology","Diphtheria","Microbiology","Repressor","Gene","Toxin","Genetics","Molecular biology","Virology","Gene expression","Vaccination"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-19T20:22:46.977210Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}