{"doi":"10.1084/jem.20250638","title":"Structural and genetic basis of HIV-1 envelope V2 apex recognition by rhesus broadly neutralizing antibodies","abstract":"Broadly neutralizing antibodies targeting the V2 apex of HIV-1 envelope are desired as vaccine design templates, but few have been described. Here, we report 11 lineages of V2 apex-neutralizing antibodies from simian-human immunodeficiency virus (SHIV)-infected rhesus macaques and determine cryo-EM structures for 9. A single V2 apex-neutralizing lineage accounted for cross-clade breadth in most macaques, and somatic hypermutation relative to breadth was generally low, exemplified by antibody V033-a.01 with <5% nucleotide mutation and 37% breadth (208-strain panel). Envelope complex structures revealed eight different antibody classes (one multi-donor) and the complete repertoire of all five possible recognition topologies, recapitulating canonical human modes of apex insertion and C-strand hydrogen bonding. Despite this diversity in recognition, all rhesus-V2 apex antibodies were derived from reading frame two of the DH3-15*01 gene. Collectively, these results define-in rhesus-the structural and genetic basis of HIV-1 V2 apex recognition and demonstrate unprecedented structural plasticity of a highly selected immunogenetic element.","journal":"The Journal of Experimental Medicine","year":2025,"id":513060,"datarank":0.4012444702170366,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.028508472748836455,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.028508472748836455,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":4,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9499,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1010058,"name":"Rumi Habib","orcid":"0000-0002-2812-8263","position":1,"is_corresponding":false},{"id":105630,"name":"Jason Gorman","orcid":"0000-0002-3775-6560","position":2,"is_corresponding":false},{"id":280543,"name":"Hui Li","orcid":"0000-0001-7231-8219","position":3,"is_corresponding":false},{"id":280553,"name":"Andrew Connell","orcid":"0000-0002-9393-3074","position":4,"is_corresponding":false},{"id":280548,"name":"Mattia Bonsignori","orcid":"0000-0003-2973-2101","position":5,"is_corresponding":false},{"id":482831,"name":"Yicheng Guo","orcid":"0000-0001-5357-660X","position":6,"is_corresponding":false},{"id":1373350,"name":"Michael P. 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