{"doi":"10.1084/jem.20241930","title":"Identification of a seasonal influenza vaccine–induced broadly protective neuraminidase antibody","abstract":"Seasonal influenza viruses cause significant global illness and death annually, and the potential spillover of avian H5N1 poses a serious pandemic threat. Traditional influenza vaccines target the variable hemagglutinin (HA) protein, necessitating annual vaccine updates, while the slower-evolving neuraminidase (NA) presents a promising target for broader protection. We investigated the breadth of anti-NA B cell responses to seasonal influenza vaccination in humans. We screened plasmablast-derived monoclonal antibodies (mAbs) from three donors, identifying 11 clonally distinct NA mAbs from 268 vaccine-specific mAbs. Among these, mAb-297 showed exceptionally broad NA inhibition, effectively protecting mice against lethal doses of influenza A and B viruses, including H5N1. We show that mAb-297 targets a common binding motif in the conserved NA active site. Our findings show that while B cell responses against NA following conventional, egg-derived influenza vaccines are rare, inducing broadly protective NA antibodies through such vaccination remains feasible, highlighting the importance of improving NA immunogens to develop a more broadly protective influenza vaccine.","journal":"The Journal of Experimental Medicine","year":2025,"id":517252,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9545,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":107142,"name":"Nisreen M.A. Okba","orcid":"0000-0002-2394-1079","position":1,"is_corresponding":false},{"id":486501,"name":"Tossapol Pholcharee","orcid":"0000-0002-5347-1936","position":2,"is_corresponding":false},{"id":361556,"name":"Hanover Matz","orcid":"0000-0002-0669-1696","position":3,"is_corresponding":false},{"id":105428,"name":"Huibin Lv","orcid":"0000-0003-2218-0076","position":4,"is_corresponding":false},{"id":1367702,"name":"Maria Ibanez Trullen","orcid":null,"position":5,"is_corresponding":false},{"id":242710,"name":"Julian Q. Zhou","orcid":"0000-0001-9602-2092","position":6,"is_corresponding":false},{"id":225532,"name":"Jackson S. Turner","orcid":"0000-0002-4396-6265","position":7,"is_corresponding":false},{"id":225533,"name":"Aaron J. Schmitz","orcid":"0000-0002-8077-6751","position":8,"is_corresponding":false},{"id":983807,"name":"Fangjie Han","orcid":null,"position":9,"is_corresponding":false},{"id":805454,"name":"Stephen Horváth","orcid":"0000-0001-5324-1666","position":10,"is_corresponding":false},{"id":439801,"name":"Sameer Kumar Malladi","orcid":"0000-0001-5131-4518","position":11,"is_corresponding":false},{"id":103779,"name":"Florian Krammer","orcid":"0000-0003-4121-776X","position":12,"is_corresponding":false},{"id":105424,"name":"Nicholas C. Wu","orcid":"0000-0002-9078-6697","position":13,"is_corresponding":false},{"id":225537,"name":"Ali H. Ellebedy","orcid":"0000-0002-6129-2532","position":14,"is_corresponding":false},{"id":932628,"name":"Anders Madsen","orcid":"0000-0002-0626-5443","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-19T02:48:59.410472Z","pmid":"40178595","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}