{"doi":"10.1084/jem.20240955","title":"Shared pathway of WDFY4-dependent cross-presentation of immune complexes by cDC1 and cDC2","abstract":"Priming CD8+ T cells against tumors or viral pathogens results largely from cross-presentation of exogenous antigens by type 1 conventional dendritic cells (cDC1s). Although monocyte-derived DCs and cDC2s can cross-present in vitro, their physiological relevance remains unclear. Here, we used genetic models to evaluate the role of cDC subsets in presentation of cell-associated and immune complex antigens to CD4+ and CD8+ T cells in vivo. For cell-associated antigens, cDC1s were necessary and sufficient to prime both CD4+ and CD8+ T cells. In contrast, for immune complex antigens, either cDC1 or cDC2, but not monocyte-derived DCs, could carry out cross-presentation to CD8+ T cells. Mice lacking cDC1 and vaccinated with immune complexes could cross-prime CD8+ T cells that were sufficient to mediate tumor rejection. Notably, this cross-presentation mediated by cDC2 was also WDFY4 dependent, similar to cross-presentation of cell-associated antigens by cDC1. These results demonstrate a previously unrecognized activity of WDFY4 in cDC2s and suggest a cross-presentation pathway shared by cDC subsets.","journal":"The Journal of Experimental Medicine","year":2025,"id":510956,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9537,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":299072,"name":"Ray A. Ohara","orcid":"0000-0001-7897-3169","position":1,"is_corresponding":false},{"id":255051,"name":"Derek J. Theisen","orcid":"0000-0002-2204-8676","position":2,"is_corresponding":false},{"id":299067,"name":"Sun Kyung Kim","orcid":"0000-0002-1375-6339","position":3,"is_corresponding":false},{"id":299070,"name":"Tiantian Liu","orcid":"0000-0001-9377-9938","position":4,"is_corresponding":false},{"id":350735,"name":"Christopher B. Bullock","orcid":"0000-0002-8081-7867","position":5,"is_corresponding":false},{"id":1368140,"name":"Michelle He","orcid":"0009-0004-1579-5595","position":6,"is_corresponding":false},{"id":395806,"name":"Feiya Ou","orcid":"0000-0001-8289-4025","position":7,"is_corresponding":false},{"id":699736,"name":"Jing Chen","orcid":"0000-0002-5998-6930","position":8,"is_corresponding":false},{"id":395489,"name":"Sytse J. Piersma","orcid":"0000-0002-5379-3556","position":9,"is_corresponding":false},{"id":302761,"name":"J. Luke Postoak","orcid":"0000-0002-2891-9938","position":10,"is_corresponding":false},{"id":276885,"name":"Wayne M. Yokoyama","orcid":"0000-0002-0566-7264","position":11,"is_corresponding":false},{"id":106529,"name":"Michael Diamond","orcid":"0000-0002-8791-3165","position":12,"is_corresponding":false},{"id":299074,"name":"Theresa L. Murphy","orcid":"0000-0001-6539-8142","position":13,"is_corresponding":false},{"id":227901,"name":"Kenneth M. Murphy","orcid":"0000-0002-3505-9630","position":14,"is_corresponding":false},{"id":1043116,"name":"Suin Jo","orcid":"0000-0002-7575-9017","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-19T02:47:50.575618Z","pmid":"39918736","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}