{"doi":"10.1084/jem.20231816","title":"Dual role of vascular endothelial growth factor-C in post-stroke recovery","abstract":"Cerebrospinal fluid (CSF), antigens, and antigen-presenting cells drain from the central nervous system (CNS) into lymphatic vessels near the cribriform plate and dura, yet the role of these vessels during stroke is unclear. Using a mouse model of ischemic stroke, transient middle cerebral artery occlusion (tMCAO), we demonstrate stroke-induced lymphangiogenesis near the cribriform plate, peaking at day 7 and regressing by day 14. Lymphangiogenesis is restricted to the cribriform plate and deep cervical lymph nodes and is regulated by VEGF-C/VEGFR-3 signaling. The use of a VEGFR-3 inhibitor prevented lymphangiogenesis and led to improved stroke outcomes at earlier time points, with no effects at later time points. VEGF-C delivery after tMCAO did not further increase post-stroke lymphangiogenesis, but instead induced larger brain infarcts. Our data support the damaging role of VEGF-C acutely and a pro-angiogenic role chronically. This nuanced understanding of VEGFR-3 and VEGF-C in stroke pathology advises caution regarding therapeutic VEGF-C use in stroke.","journal":"The Journal of Experimental Medicine","year":2024,"id":428034,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9578,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":576273,"name":"Martin Hsu","orcid":"0000-0003-1210-6497","position":1,"is_corresponding":false},{"id":576275,"name":"Collin Laaker","orcid":"0000-0001-8532-9427","position":2,"is_corresponding":false},{"id":934651,"name":"Jenna Port","orcid":"0000-0001-5968-7626","position":3,"is_corresponding":false},{"id":1034881,"name":"Kristof Kovacs","orcid":"0000-0001-9576-641X","position":4,"is_corresponding":false},{"id":576276,"name":"Melinda Herbáth","orcid":"0000-0002-8403-582X","position":5,"is_corresponding":false},{"id":1163829,"name":"Heeyoon Yang","orcid":null,"position":6,"is_corresponding":false},{"id":655404,"name":"Peter Cismaru","orcid":"0000-0002-9541-2846","position":7,"is_corresponding":false},{"id":711712,"name":"Alexis M. Johnson","orcid":"0000-0003-2943-6847","position":8,"is_corresponding":false},{"id":1163830,"name":"Bailey Spellman","orcid":null,"position":9,"is_corresponding":false},{"id":1163831,"name":"Kelsey Wigand","orcid":null,"position":10,"is_corresponding":false},{"id":576277,"name":"Mátyás Sándor","orcid":"0000-0001-6463-6807","position":11,"is_corresponding":false},{"id":576278,"name":"Zsuzsanna Fábry","orcid":"0000-0003-4555-9732","position":12,"is_corresponding":false},{"id":576274,"name":"Yun Hwa Choi","orcid":"0000-0002-9344-6110","position":0,"is_corresponding":true}],"reference_count":85,"raw_metadata":null,"created_at":"2026-07-19T01:58:57.592578Z","pmid":"39665829","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}