{"doi":"10.1084/jem.20231717","title":"CD301b+ monocyte-derived dendritic cells mediate resistance to radiotherapy","abstract":"Monocytes infiltrating tumors acquire various states that distinctly impact cancer treatment. Here, we show that resistance of tumors to radiotherapy (RT) is controlled by the accumulation of monocyte-derived dendritic cells (moDCs). These moDCs are characterized by the expression of CD301b and have a superior capacity to generate regulatory T cells (Tregs). Accordingly, moDC depletion limits Treg generation and improves the therapeutic outcome of RT. Mechanistically, we demonstrate that granulocyte-macrophage colony-stimulating factor (GM-CSF) derived from radioresistant tumor cells following RT is necessary for the accumulation of moDCs. Our results unravel the immunosuppressive function of moDCs and identify GM-CSF as an immunotherapeutic target during RT.","journal":"The Journal of Experimental Medicine","year":2025,"id":511492,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9529,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":790255,"name":"Derek R. Clements","orcid":"0000-0002-0796-8845","position":1,"is_corresponding":false},{"id":74129,"name":"Hayley M. Raquer-McKay","orcid":"0000-0002-7404-8221","position":2,"is_corresponding":false},{"id":1042118,"name":"Anja Lüdtke","orcid":null,"position":3,"is_corresponding":false},{"id":413608,"name":"Sanjana Saravanan","orcid":"0000-0002-5974-7710","position":4,"is_corresponding":false},{"id":1021369,"name":"David Seong","orcid":"0000-0002-8980-5731","position":5,"is_corresponding":false},{"id":1370229,"name":"Lorraine Vitek","orcid":null,"position":6,"is_corresponding":false},{"id":227954,"name":"Christopher M. Richards","orcid":"0000-0003-0832-8951","position":7,"is_corresponding":false},{"id":227957,"name":"Jan E. Carette","orcid":"0000-0002-5187-8070","position":8,"is_corresponding":false},{"id":471317,"name":"Matthias Mack","orcid":"0000-0002-3157-7262","position":9,"is_corresponding":false},{"id":495395,"name":"Andres Gottfried‐Blackmore","orcid":"0000-0002-3563-3727","position":10,"is_corresponding":false},{"id":232620,"name":"Edward E. Graves","orcid":"0000-0003-4265-9041","position":11,"is_corresponding":false},{"id":74114,"name":"Juliana Idoyaga","orcid":"0000-0002-4430-8862","position":12,"is_corresponding":false},{"id":874879,"name":"Sirimuvva Tadepalli","orcid":"0000-0001-9658-9988","position":0,"is_corresponding":true}],"reference_count":94,"raw_metadata":null,"created_at":"2026-07-19T02:47:55.918021Z","pmid":"40146036","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}