{"doi":"10.1084/jem.20231464","title":"Human neutrophils drive skin autoinflammation by releasing interleukin (IL)-26","abstract":"Autoinflammation is a sterile inflammatory process resulting from increased neutrophil infiltration and overexpression of IL-1 cytokines. The factors that trigger these events are, however, poorly understood. By investigating pustular forms of psoriasis, we show that human neutrophils constitutively express IL-26 and abundantly release it from granular stores upon activation. In pustular psoriasis, neutrophil-derived IL-26 drives the pathogenic autoinflammation process by inducing the expression of IL-1 cytokines and chemokines that further recruit neutrophils. This occurs via activation of IL-26R in keratinocytes and via the formation of complexes between IL-26 and microbiota DNA, which trigger TLR9 activation of neutrophils. Thus our findings identify neutrophils as an important source of IL-26 and point to IL-26 as the key link between neutrophils and a self-sustaining autoinflammation loop in pustular psoriasis.","journal":"The Journal of Experimental Medicine","year":2024,"id":423655,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9474,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1219394,"name":"Jérémy Di Domizio","orcid":"0000-0002-6281-3918","position":1,"is_corresponding":false},{"id":844005,"name":"Ahmad Yatim","orcid":"0000-0002-4859-4085","position":2,"is_corresponding":false},{"id":1219395,"name":"Sophie Vandenberghe-Dürr","orcid":"0009-0004-3289-953X","position":3,"is_corresponding":false},{"id":1219396,"name":"Raphael Jenelten","orcid":"0000-0002-0122-8918","position":4,"is_corresponding":false},{"id":1219397,"name":"Anissa Fries","orcid":"0009-0003-7414-4728","position":5,"is_corresponding":false},{"id":1219398,"name":"Lorenzo Grizzetti","orcid":"0009-0007-9542-4576","position":6,"is_corresponding":false},{"id":669297,"name":"François Kuonen","orcid":"0000-0001-6137-7483","position":7,"is_corresponding":false},{"id":1007044,"name":"C. Paul","orcid":"0000-0003-0165-5263","position":8,"is_corresponding":false},{"id":236685,"name":"Robert L. Modlin","orcid":"0000-0003-4720-031X","position":9,"is_corresponding":false},{"id":12811,"name":"Curdin Conrad","orcid":"0000-0002-2547-3440","position":10,"is_corresponding":false},{"id":1219399,"name":"Michel Gilliet","orcid":"0000-0002-4609-3762","position":11,"is_corresponding":false},{"id":1074598,"name":"Alessia Baldo","orcid":"0000-0002-8072-744X","position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":null,"created_at":"2026-07-19T01:58:01.889748Z","pmid":"38448036","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}