{"doi":"10.1084/jem.20231144","title":"Regenerating murine CD8+ lung tissue resident memory T cells after targeted radiation exposure","abstract":"Radiation exposure occurs during medical procedures, nuclear accidents, or spaceflight, making effective medical countermeasures a public health priority. Naïve T cells are highly sensitive to radiation-induced depletion, although their numbers recover with time. Circulating memory CD8+ T cells are also depleted by radiation; however, their numbers do not recover. Critically, the impact of radiation exposure on tissue-resident memory T cells (TRM) remains unknown. Here, we found that sublethal thorax-targeted radiation resulted in the rapid and prolonged numerical decline of influenza A virus (IAV)-specific lung TRM in mice, but no decline in antigen-matched circulating memory T cells. Prolonged loss of lung TRM was associated with decreased heterosubtypic immunity. Importantly, boosting with IAV-epitope expressing pathogens that replicate in the lungs or peripheral tissues or with a peripherally administered mRNA vaccine regenerated lung TRM that was derived largely from circulating memory CD8+ T cells. Designing effective vaccination strategies to regenerate TRM will be important in combating the immunological effects of radiation exposure.","journal":"The Journal of Experimental Medicine","year":2024,"id":436211,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9513,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":680505,"name":"Lecia L. Pewe","orcid":"0000-0002-6134-630X","position":1,"is_corresponding":false},{"id":1244308,"name":"Rui He","orcid":"0009-0002-6676-5578","position":2,"is_corresponding":false},{"id":1037954,"name":"Mohammad Heidarian","orcid":"0000-0001-5050-140X","position":3,"is_corresponding":false},{"id":925865,"name":"Pornpoj Phruttiwanichakun","orcid":"0000-0003-3045-3919","position":4,"is_corresponding":false},{"id":680508,"name":"Stephanie van de Wall","orcid":"0009-0002-9707-3814","position":5,"is_corresponding":false},{"id":680510,"name":"Madison R. Mix","orcid":"0000-0002-2173-608X","position":6,"is_corresponding":false},{"id":287601,"name":"Aliasger K. Salem","orcid":"0000-0002-1923-6633","position":7,"is_corresponding":false},{"id":250878,"name":"Vladimir P. Badovinac","orcid":"0000-0003-3180-2439","position":8,"is_corresponding":false},{"id":397894,"name":"John T. Harty","orcid":"0000-0001-7266-2802","position":9,"is_corresponding":false},{"id":409037,"name":"Mariah Hassert","orcid":"0000-0002-2141-3344","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-19T02:00:12.706156Z","pmid":"38363548","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}