{"doi":"10.1084/jem.20230263","title":"B cell–intrinsic <i>Myd88</i> regulates disease progression in murine lupus","abstract":"Nucleic acid-specific Toll-like receptors (TLRs) have been implicated in promoting disease pathogenesis in systemic lupus erythematosus (SLE). Whether such TLRs mediate disease onset, progression, or both remains undefined; yet the answer to this question has important therapeutic implications. MyD88 is an essential adaptor that acts downstream of IL-1 family receptors and most TLRs. Both global and B cell-specific Myd88 deficiency ameliorated disease in lupus-prone mice when constitutively deleted. To address whether Myd88 was needed to sustain ongoing disease, we induced B cell-specific deletion of Myd88 after disease onset in MRL.Faslpr mice using an inducible Cre recombinase. B cell-specific deletion of Myd88 starting after disease onset resulted in ameliorated glomerulonephritis and interstitial inflammation. Additionally, treated mice had reduced autoantibody formation and an altered B cell compartment with reduced ABC and plasmablast numbers. These experiments demonstrate the role of MyD88 in B cells to sustain disease in murine lupus. Therefore, targeting MyD88 or its upstream activators may be a viable therapeutic option in SLE.","journal":"The Journal of Experimental Medicine","year":2023,"id":341704,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9507,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1077699,"name":"Min-Jung Kim","orcid":"0009-0009-0749-7826","position":1,"is_corresponding":false},{"id":284014,"name":"Rachael A. Gordon","orcid":"0000-0001-6598-0546","position":2,"is_corresponding":false},{"id":284015,"name":"Claire Leibler","orcid":"0000-0001-7787-2817","position":3,"is_corresponding":false},{"id":1031836,"name":"Haylee A. Cosgrove","orcid":"0000-0003-3478-3835","position":4,"is_corresponding":false},{"id":284017,"name":"Sheldon Bastacky","orcid":"0000-0002-3173-5048","position":5,"is_corresponding":false},{"id":284018,"name":"Kevin M. Nickerson","orcid":"0000-0002-0114-2671","position":6,"is_corresponding":false},{"id":237080,"name":"Mark J. Shlomchik","orcid":"0000-0002-2152-0959","position":7,"is_corresponding":false},{"id":284013,"name":"Jeremy S. Tilstra","orcid":"0000-0003-0877-9971","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-19T01:11:08.077724Z","pmid":"37787782","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}