{"doi":"10.1084/jem.20222052","title":"The interweaved signatures of common-gamma-chain cytokines across immunologic lineages","abstract":"\"γc\" cytokines are a family whose receptors share a \"common-gamma-chain\" signaling moiety, and play central roles in differentiation, homeostasis, and communications of all immunocyte lineages. As a resource to better understand their range and specificity of action, we profiled by RNAseq the immediate-early responses to the main γc cytokines across all immunocyte lineages. The results reveal an unprecedented landscape: broader, with extensive overlap between cytokines (one cytokine doing in one cell what another does elsewhere) and essentially no effects unique to any one cytokine. Responses include a major downregulation component and a broad Myc-controlled resetting of biosynthetic and metabolic pathways. Various mechanisms appear involved: fast transcriptional activation, chromatin remodeling, and mRNA destabilization. Other surprises were uncovered: IL2 effects in mast cells, shifts between follicular and marginal zone B cells, paradoxical and cell-specific cross-talk between interferon and γc signatures, or an NKT-like program induced by IL21 in CD8+ T cells.","journal":"The Journal of Experimental Medicine","year":2023,"id":338212,"datarank":0.4335557636844247,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.0,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9457,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":618279,"name":"Kumba Seddu","orcid":"0000-0002-0875-5833","position":1,"is_corresponding":false},{"id":1070620,"name":"Tamara Salloum","orcid":"0000-0002-2689-4175","position":2,"is_corresponding":false},{"id":1070621,"name":"Caleb A. Dawson","orcid":"0000-0002-6835-6930","position":3,"is_corresponding":false},{"id":1070622,"name":"Juliana J. Lee","orcid":"0000-0002-7393-9997","position":4,"is_corresponding":false},{"id":552217,"name":"Liang Yang","orcid":"0009-0007-2903-641X","position":5,"is_corresponding":false},{"id":297345,"name":"Shani T. Gal-Oz","orcid":"0000-0001-7775-2006","position":6,"is_corresponding":false},{"id":282857,"name":"Hadas Ner‐Gaon","orcid":"0000-0002-6288-5065","position":7,"is_corresponding":false},{"id":618281,"name":"Julie Tellier","orcid":"0000-0003-2787-8174","position":8,"is_corresponding":false},{"id":572158,"name":"Alberto J. Millan","orcid":"0000-0003-1186-7219","position":9,"is_corresponding":false},{"id":1070623,"name":"Alexander Sasse","orcid":"0000-0001-7031-8848","position":10,"is_corresponding":false},{"id":105231,"name":"Brian D. Brown","orcid":"0000-0002-3670-8778","position":11,"is_corresponding":false},{"id":61587,"name":"Lewis L. Lanier","orcid":"0000-0003-1308-3952","position":12,"is_corresponding":false},{"id":16659,"name":"Tal Shay","orcid":"0000-0003-0755-1350","position":13,"is_corresponding":false},{"id":588727,"name":"Stephen L. Nutt","orcid":"0000-0002-0020-6637","position":14,"is_corresponding":false},{"id":104337,"name":"Daniel F. Dwyer","orcid":"0000-0001-5029-261X","position":15,"is_corresponding":false},{"id":18715,"name":"Christophe Benoıst","orcid":"0000-0003-1172-6555","position":16,"is_corresponding":false},{"id":297327,"name":"Alev Baysoy","orcid":"0000-0001-5526-5848","position":0,"is_corresponding":true}],"reference_count":58,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:10:35.973121Z","pmid":"36976164","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}