{"doi":"10.1084/jem.20221717","title":"Progressive differentiation toward the long-lived plasma cell compartment in the bone marrow","abstract":"<jats:p>The longevity of plasma cells is dependent on their ability to access and reside in so-called niches that are predominantly located in the bone marrow. Here, by employing a traceable method to label recently generated plasma cells, we showed that homeostatic plasma cells in the bone marrow and spleen were continuously replenished by newly generated B220hiMHC-IIhi populations that progressively differentiated into B220loMHC-IIlo long-lived plasma cell (LLPC) populations. We also found that, in the bone marrow, germinal center (GC)–independent and GC-dependent plasma cells decayed similarly upon NP-CGG engagement, and both entered the B220loMHC-IIlo LLPC pool. Compared with NP+B220hiMHC-IIhi plasma cells, NP+B220loMHC-IIlo cells were more immobilized in the bone marrow niches and showed better survival potential. Thus, our results suggest that the adhesion status of bone marrow plasma cells is dynamically altered during their differentiation and is associated with provision of survival signals.</jats:p>","journal":"Journal of Experimental Medicine","year":2023,"id":596010,"datarank":0.6394019815561974,"base_score":4.2626798770413155,"endowment":4.2626798770413155,"self_citation_contribution":0.6394019815561974,"citation_network_contribution":0.0,"self_endowment_contribution":0.6394019815561974,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":70,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":215869,"name":"Kentaro Fujii","orcid":"0000-0002-3692-493X","position":1,"is_corresponding":false},{"id":623479,"name":"Kohei Kometani","orcid":"0000-0003-4281-4371","position":2,"is_corresponding":false},{"id":271045,"name":"Noah S. Butler","orcid":"0000-0002-1429-0796","position":3,"is_corresponding":false},{"id":1526422,"name":"Kenji Funakoshi","orcid":"0000-0002-1757-6925","position":4,"is_corresponding":false},{"id":1526423,"name":"Shinya Yari","orcid":"0000-0001-7915-5926","position":5,"is_corresponding":false},{"id":1526424,"name":"Junichi Kikuta","orcid":"0000-0002-1549-5961","position":6,"is_corresponding":false},{"id":499125,"name":"Masaru Ishii","orcid":"0000-0002-4215-007X","position":7,"is_corresponding":false},{"id":623480,"name":"Tomohiro Kurosaki","orcid":"0000-0002-6352-304X","position":8,"is_corresponding":false},{"id":813590,"name":"Wataru Ise","orcid":"0000-0003-0457-3386","position":9,"is_corresponding":false},{"id":1526421,"name":"Takuya Koike","orcid":"0000-0002-4193-6679","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Progressive differentiation toward the long-lived plasma cell compartment in the bone marrow","abstract":"<jats:p>The longevity of plasma cells is dependent on their ability to access and reside in so-called niches that are predominantly located in the bone marrow. Here, by employing a traceable method to label recently generated plasma cells, we showed that homeostatic plasma cells in the bone marrow and spleen were continuously replenished by newly generated B220hiMHC-IIhi populations that progressively differentiated into B220loMHC-IIlo long-lived plasma cell (LLPC) populations. We also found that, in the bone marrow, germinal center (GC)–independent and GC-dependent plasma cells decayed similarly upon NP-CGG engagement, and both entered the B220loMHC-IIlo LLPC pool. Compared with NP+B220hiMHC-IIhi plasma cells, NP+B220loMHC-IIlo cells were more immobilized in the bone marrow niches and showed better survival potential. Thus, our results suggest that the adhesion status of bone marrow plasma cells is dynamically altered during their differentiation and is associated with provision of survival signals.</jats:p>","is_dataset_classified":null,"base_score":4.2626798770413155,"endowment":4.2626798770413155,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36515679","pmcid":"PMC9754767","openalex_id":"https://openalex.org/W4311470771","authors":[],"funders":[{"funder_name":"Grand-in-Aid for JSPS Fellows","grant_id":"JP22J00313","title":null},{"funder_name":"Grand-in-Aid for Young Scientists","grant_id":"JP20K16283","title":null},{"funder_name":"Japan Society for the Promotion of Science KAKENHI","grant_id":"JP22H00450","title":null},{"funder_name":"Japan Society for the Promotion of Science KAKENHI","grant_id":"JP18KK0227","title":null},{"funder_name":"Japan Society for the Promotion of Science KAKENHI","grant_id":"JP20H03503","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R01 AI127481","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R01 AI167058","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R01 AI125446","title":null},{"funder_name":"Naito Foundation","grant_id":"","title":null},{"funder_name":"Uehara Memorial Foundation","grant_id":"","title":null},{"funder_name":"Nippon Foundation","grant_id":"","title":null},{"funder_name":"Daiichi Sankyo Foundation of Life Science","grant_id":"","title":null},{"funder_name":"Otsuka Pharmaceutical Co., Ltd.","grant_id":"","title":null},{"funder_name":"SENSHIN Medical Research Foundation","grant_id":"","title":null}],"total_grants":14,"fwci":4.8585,"citation_percentile":0.96481069,"influential_citations":0,"citation_trend":[{"year":2023,"count":13},{"year":2024,"count":19},{"year":2025,"count":26},{"year":2026,"count":12}],"oa_status":"green","license":"http://www.rupress.org/terms/","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9754767","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9754767","host_type":"repository"},{"url":"https://rupress.org/jem/article-pdf/doi/10.1084/jem.20221717/1445193/jem_20221717.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1084/jem.20221717","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36515679","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9754767","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9754767?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["T-cell and B-cell Immunology","Hematopoietic Stem Cell Transplantation","Erythrocyte Function and Pathophysiology"],"mesh_terms":["Bone Marrow","Bone Marrow Cells","Cell Differentiation","Cell Survival","Plasma Cells","Germinal Center"],"keywords":["Bone marrow","Plasma cell","Spleen","Biology","Cell biology","Immunology"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T18:57:52.253455Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}