{"doi":"10.1084/jem.20221604","title":"Identification of an anergic BND cell–derived activated B cell population (BND2) in young-onset type 1 diabetes patients","abstract":"Recent evidence suggests a role for B cells in the pathogenesis of young-onset type 1 diabetes (T1D), wherein rapid progression occurs. However, little is known regarding the specificity, phenotype, and function of B cells in young-onset T1D. We performed a cross-sectional analysis comparing insulin-reactive to tetanus-reactive B cells in the blood of T1D and controls using mass cytometry. Unsupervised clustering revealed the existence of a highly activated B cell subset we term BND2 that falls within the previously defined anergic BND subset. We found a specific increase in the frequency of insulin-reactive BND2 cells in the blood of young-onset T1D donors, which was further enriched in the pancreatic lymph nodes of T1D donors. The frequency of insulin-binding BND2 cells correlated with anti-insulin autoantibody levels. We demonstrate BND2 cells are pre-plasma cells and can likely act as APCs to T cells. These findings identify an antigen-specific B cell subset that may play a role in the rapid progression of young-onset T1D.","journal":"The Journal of Experimental Medicine","year":2023,"id":332013,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.955,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1057526,"name":"Christopher A. Magera","orcid":"0009-0009-3904-9382","position":1,"is_corresponding":false},{"id":764242,"name":"Hali Broncucia","orcid":"0000-0003-2056-2169","position":2,"is_corresponding":false},{"id":1057527,"name":"B. Gómez","orcid":"0000-0002-3871-3773","position":3,"is_corresponding":false},{"id":1057528,"name":"Nasha M. Rios-Guzman","orcid":"0000-0003-3258-2335","position":4,"is_corresponding":false},{"id":282722,"name":"Kristen L. Wells","orcid":"0000-0002-7466-8164","position":5,"is_corresponding":false},{"id":1057529,"name":"Catherine A. Nicholas","orcid":"0000-0003-2724-266X","position":6,"is_corresponding":false},{"id":776130,"name":"Marynette Rihanek","orcid":"0009-0003-2274-4318","position":7,"is_corresponding":false},{"id":1057530,"name":"M. Hunter","orcid":"0009-0006-4694-7058","position":8,"is_corresponding":false},{"id":1057531,"name":"Kevin P. Toole","orcid":"0009-0003-2694-5141","position":9,"is_corresponding":false},{"id":336608,"name":"Peter A. Gottlieb","orcid":"0000-0002-7601-8536","position":10,"is_corresponding":false},{"id":497335,"name":"Mia J. Smith","orcid":"0000-0003-3042-5061","position":11,"is_corresponding":false},{"id":776129,"name":"Zachary C. Stensland","orcid":"0009-0002-5900-5140","position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":null,"created_at":"2026-07-19T01:09:25.015646Z","pmid":"37184563","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}