{"doi":"10.1084/jem.20221518","title":"SARS-CoV-2 infection and recovery in children: Distinct T cell responses in MIS-C compared to COVID-19","abstract":"SARS-CoV-2 infection for most children results in mild or minimal symptoms, though in rare cases severe disease can develop, including a multisystem inflammatory syndrome (MIS-C) with myocarditis. Here, we present longitudinal profiling of immune responses during acute disease and following recovery in children who developed MIS-C, relative to children who experienced more typical symptoms of COVID-19. T cells in acute MIS-C exhibited transient signatures of activation, inflammation, and tissue residency which correlated with cardiac disease severity, while T cells in acute COVID-19 upregulated markers of follicular helper T cells for promoting antibody production. The resultant memory immune response in recovery showed increased frequencies of virus-specific memory T cells with pro-inflammatory functions in children with prior MIS-C compared to COVID-19 while both cohorts generated comparable antibody responses. Together our results reveal distinct effector and memory T cell responses in pediatric SARS-CoV-2 infection delineated by clinical syndrome, and a potential role for tissue-derived T cells in the immune pathology of systemic disease.","journal":"The Journal of Experimental Medicine","year":2023,"id":332000,"datarank":0.4943755299006494,"base_score":3.295836866004329,"endowment":3.295836866004329,"self_citation_contribution":0.4943755299006494,"citation_network_contribution":0.0,"self_endowment_contribution":0.4943755299006494,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9562,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1057510,"name":"Joseph Bell","orcid":"0000-0001-6681-0741","position":1,"is_corresponding":false},{"id":621512,"name":"Marissa C. Bradley","orcid":"0000-0001-9987-4119","position":2,"is_corresponding":false},{"id":1057511,"name":"Teddy John Wohlbold","orcid":"0000-0003-0982-6004","position":3,"is_corresponding":false},{"id":1058002,"name":"Marika Scafuro","orcid":null,"position":4,"is_corresponding":false},{"id":108193,"name":"Wenzhao Meng","orcid":"0000-0002-8040-7825","position":5,"is_corresponding":false},{"id":1057512,"name":"Rebecca C. Korenberg","orcid":"0009-0001-3769-0047","position":6,"is_corresponding":false},{"id":225931,"name":"Julia Davis‐Porada","orcid":"0000-0001-9313-4590","position":7,"is_corresponding":false},{"id":289367,"name":"Brett R. Anderson","orcid":"0000-0002-0450-9387","position":8,"is_corresponding":false},{"id":533561,"name":"Rachel Weller","orcid":"0000-0002-5877-1604","position":9,"is_corresponding":false},{"id":225938,"name":"Joshua D. Milner","orcid":"0000-0002-3913-3869","position":10,"is_corresponding":false},{"id":225939,"name":"Anne Moscona","orcid":"0000-0002-1796-8320","position":11,"is_corresponding":false},{"id":225940,"name":"Matteo Porotto","orcid":"0000-0003-3866-9220","position":12,"is_corresponding":false},{"id":244597,"name":"Eline T. Luning Prak","orcid":"0000-0002-9478-9211","position":13,"is_corresponding":false},{"id":1020789,"name":"Kalpana Pethe","orcid":"0000-0001-5318-1886","position":14,"is_corresponding":false},{"id":225921,"name":"Thomas J. Connors","orcid":"0000-0002-0199-7733","position":15,"is_corresponding":false},{"id":225941,"name":"Donna L. Färber","orcid":"0000-0001-8236-9183","position":16,"is_corresponding":false},{"id":396302,"name":"Ksenia Rybkina","orcid":null,"position":0,"is_corresponding":true}],"reference_count":91,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:09:25.015646Z","pmid":"37133746","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}