{"doi":"10.1084/jem.20221346","title":"Age-associated B cells are heterogeneous and dynamic drivers of autoimmunity in mice","abstract":"Age-associated B cells (ABCs) are formed under inflammatory conditions and are considered a type of memory B cell (MBC) expressing the transcription factor T-bet. In SLE, ABC frequency is correlated with disease, and they are thought to be the source of autoantibody-secreting cells. However, in inflammatory conditions, whether autoreactive B cells can become resting MBCs is uncertain. Further, the phenotypic identity of ABCs and their relationship to other B cell subsets, such as plasmablasts, is unclear. Whether ABCs directly promote disease is untested. Here we report, in the MRL/lpr SLE model, unexpected heterogeneity among ABC-like cells for expression of the integrins CD11b and CD11c, T-bet, and memory or plasmablast markers. Transfer and labeling studies demonstrated that ABCs are dynamic, rapidly turning over. scRNA-seq identified B cell clones present in multiple subsets, revealing that ABCs can be plasmablast precursors or undergo cycles of reactivation. Deletion of CD11c-expressing B cells revealed a direct role for ABC-like B cells in lupus pathogenesis.","journal":"The Journal of Experimental Medicine","year":2023,"id":315941,"datarank":0.7278045395879427,"base_score":4.852030263919617,"endowment":4.852030263919617,"self_citation_contribution":0.7278045395879427,"citation_network_contribution":0.0,"self_endowment_contribution":0.7278045395879427,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":127,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9461,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":237073,"name":"Shuchi Smita","orcid":"0000-0001-9276-8145","position":1,"is_corresponding":false},{"id":255166,"name":"Kenneth B. Hoehn","orcid":"0000-0003-0411-4307","position":2,"is_corresponding":false},{"id":312003,"name":"Anthony Marinov","orcid":"0000-0003-3876-747X","position":3,"is_corresponding":false},{"id":857632,"name":"Kayla Thomas","orcid":"0000-0003-0533-1557","position":4,"is_corresponding":false},{"id":490210,"name":"Justin T. Kos","orcid":"0000-0003-2645-3641","position":5,"is_corresponding":false},{"id":1018356,"name":"Yi Yang","orcid":"0000-0002-6967-982X","position":6,"is_corresponding":false},{"id":284017,"name":"Sheldon Bastacky","orcid":"0000-0002-3173-5048","position":7,"is_corresponding":false},{"id":51382,"name":"Corey T. Watson","orcid":"0000-0001-7248-8787","position":8,"is_corresponding":false},{"id":6493,"name":"Steven H. Kleinstein","orcid":"0000-0003-4957-1544","position":9,"is_corresponding":false},{"id":237080,"name":"Mark J. Shlomchik","orcid":"0000-0002-2152-0959","position":10,"is_corresponding":false},{"id":284018,"name":"Kevin M. Nickerson","orcid":"0000-0002-0114-2671","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:06:32.274501Z","pmid":"36828389","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}